DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG30414

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_001163264.1	Gene:	CG30414 / 37705	FlyBaseID:	FBgn0050414	Length:	305	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	93/325 - (28%)
Similarity:	133/325 - (40%)	Gaps:	76/325 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   134 YVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRF--KIIGGEFTTIENQPWFAAI 196
            ::..||.|||       |:......:|...|...||  |.:|.|  .|.||....:.:.||...:
  Fly     3 FIAAGLALLV-------CSIQLGEGAPGHLLDSSCG--TTKPEFIPMITGGADAGLFSNPWMVKV 58

Human   197 YRRHRGGSVTYVCGGSLISPCWVISATHCFID-------------YPKKE-------DYIVYLGR 241
            ....       :||||||:..:|::|.||.:.             :|.|:       .|  .|.|
  Fly    59 LGEK-------LCGGSLITSRFVLTAAHCIVSTHMRVRLGEYKTRFPGKDCSRCVPKSY--KLRR 114

Human   242 SRL---NSNTQGE-------MKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQ 296
            .||   ::...|:       .:..|:..|||.||:   |...|||.||:::|    ..|.|..::
  Fly   115 IRLGEYDTRFPGKDCCVPKSYELAVDRKILHADYN---LNLDNDIGLLRMKS----FVQYSDYVR 172

Human   297 TICL---PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTK 358
            .|||   ..|...|.|    .|||:|..|  |.....:|:...|.......|:..  :..:|...
  Fly   173 PICLLVEGHMAESPIF----NITGWGVTN--DGTPSRRLQRATVYNTDLHFCRSK--FTKQVDES 229

Human   359 MLCAADPQWKTDSCQGDSGGPLVCSLQ-GRMTLT---GIVSWGRGCALKDKPGVYTRVSHFLPWI 419
            .:|||..  .:|:|.|||||||...:. ....||   |:||:  |.|......|||.|:|...||
  Fly   230 QICAAGT--NSDACHGDSGGPLSAQVPFAGSWLTFQYGLVSY--GSAACHSFSVYTNVTHHRDWI 290

Human 420 419
Fly 291 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	5/17 (29%)
		Connecting peptide	152..177		6/24 (25%)
		Tryp_SPc	179..422	CDD:238113	80/278 (29%)
CG30414	NP_001163264.1	Tryp_SPc	41..290	CDD:214473	78/276 (28%)
CG30414	NP_001163264.1	Tryp_SPc	41..290	CDD:238113	78/276 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910