DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and scaf

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_610180.1	Gene:	scaf / 35505	FlyBaseID:	FBgn0033033	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	91/356 - (25%)
Similarity:	129/356 - (36%)	Gaps:	88/356 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    95 NSATVLQQT----------YHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVH 149
            |:..||.:|          :....:|.||...|....|....|...||.....|:
  Fly   357 NAIGVLSETPVELSPMEAAFRVPLTDCLQTENGSPGKCCRDPNYVDPWPVNLAGV---------- 411

Human   150 DCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLI 214
             ||...|.:.|       .|.|.|...|..|          ||.|.|.|.   .|.|.:|||::|
  Fly   412 -CATRNKRTKP-------TGVKDLDANFAEI----------PWQAMILRE---SSKTLICGGAII 455

Human   215 SPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFE---VENLILHKDYSADTLAHHNDI 276
            ...:|:|:..|....| ..|..|..|...|.| |...:.|:   |:.:.:|.||...|.:|  |:
  Fly   456 GDQFVLSSASCVNGLP-VTDIRVKAGEWELGS-TNEPLPFQLTGVKTVDVHPDYDPSTNSH--DL 516

Human   277 ALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 341
            |::::.    |..:.:..||.||:..  .||:....|..:|:||:                .|..
  Fly   517 AIIRLE----RRLEFASHIQPICISD--EDPKDSEQCFTSGWGKQ----------------ALSI 559

Human   342 HRECQQPHYYGSEVTTKMLCAADPQ-----WKTDSCQGDSGGPLVCSLQGRMTLTGIV----SWG 397
            |.|....|...:....:..|:||..     .|.||||.|.|..|.|.....:.|.||.    |.|
  Fly   560 HEEGALMHVTDTLPQARSECSADSSSVCSATKFDSCQFDVGSALACGSGSSVRLKGIFAGENSCG 624

Human   398 RGCALK-DKPGVYTRVSHFLPWIRSHTKEEN 427
            .|..:: .||.:        .||.:...|.|
  Fly   625 EGQTVRFAKPDI--------KWINTAFAENN 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	13/66 (20%)
		Connecting peptide	152..177		6/24 (25%)
		Tryp_SPc	179..422	CDD:238113	68/255 (27%)
scaf	NP_610180.1	FtsK	<198..>334	CDD:332908
scaf	NP_610180.1	Tryp_SPc	428..616	CDD:238113	60/226 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910