DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG9673

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_001285346.1	Gene:	CG9673 / 32649	FlyBaseID:	FBgn0030775	Length:	261	Species:	Drosophila melanogaster

Alignment Length:	264	Identity:	69/264 - (26%)
Similarity:	115/264 - (43%)	Gaps:	41/264 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   175 PRFKIIGGEFTTIENQPWFAAI-YRRHRGGSVTYVCGGSLISPCWVISATHCF----IDYPKKED 234
            |:.:|:|||.......||.|:: |.:      .:||.|::||...:::|.||.    |.......
  Fly    25 PQGRILGGEDVAQGEYPWSASVRYNK------AHVCSGAIISTNHILTAAHCVSSVGITPVDAST 83

Human   235 YIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTIC 299
            ..|.||  .:|....|.: ..|:::|:|..|.  ...|  |||:|::    ......|..||.|.
  Fly    84 LAVRLG--TINQYAGGSI-VNVKSVIIHPSYG--NFLH--DIAILEL----DETLVFSDRIQDIA 137

Human   300 LPSMYND---------PQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEV 355
            ||...::         |. ||...:.|:|:.:.....|.:|  ......:|...|:....||.|
  Fly   138 LPPTTDEETEDVDAELPN-GTPVYVAGWGELSDGTASYKQQ--KANYNTLSRSLCEWEAGYGYE- 198

Human   356 TTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR 420
              .::|.:..:.: ..|:||:|..::   .....|.|:.|:..|......|.|.||||::|.||.
  Fly   199 --SVVCLSRAEGE-GICRGDAGAAVI---DDDKVLRGLTSFNFGPCGSKYPDVATRVSYYLTWIE 257

Human   421 SHTK 424
            ::|:
  Fly   258 ANTQ 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		1/1 (100%)
		Tryp_SPc	179..422	CDD:238113	67/256 (26%)
CG9673	NP_001285346.1	Tryp_SPc	28..256	CDD:214473	65/254 (26%)
CG9673	NP_001285346.1	Tryp_SPc	29..259	CDD:238113	67/256 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910