DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG31827

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_723923.1	Gene:	CG31827 / 318965	FlyBaseID:	FBgn0051827	Length:	294	Species:	Drosophila melanogaster

Alignment Length:	279	Identity:	87/279 - (31%)
Similarity:	126/279 - (45%)	Gaps:	34/279 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   162 EELKFQCG---QKTLRPRFKIIGGEFTTIENQPW-FAAIYRRHRGGSVTYVCGGSLISPCWVISA 222
            ||||  ||   ...::.:|.:..|:....| .|| .|.|:.|      :.|.|||||:|..|::|
  Fly    27 EELK--CGYGNPDAVKVQFNVTEGQAKPAE-FPWTIAVIHNR------SLVGGGSLITPDIVLTA 82

Human   223 THCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFE---VENLILHKDYSADTLAHHNDIALLKIRSK 284
            .|...: ...||.:|..|.....|..: :..||   |..:::||.::....|  |::|||.:
  Fly    83 AHRIFN-KDVEDIVVSAGEWEYGSALE-KYPFEEAFVLKMVIHKSFNYQRGA--NNLALLFL--- 140

Human   285 EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQ--- 346
             .|....:..|.|||||:...... .|.|.:.|:||...:|..|...||...:.::....||
  Fly   141 -DREFPLTYKINTICLPTQKRSLS-STRCIVAGWGKYQFSDTHYGGVLKKIDLPIVPRHICQDQL 203

Human   347 QPHYYGSEVTTK--MLCAADPQWKTDSCQGDSGGPLVCSL---QGRMTLTGIVSWGRGCALKDKP 406
            :....|...|..  ::||...: ..|:|.||.||.|.|.:   ..:....|||:||.||..|:.|
  Fly   204 RKTRLGQNYTLPRGLICAGGEK-DNDACTGDGGGALFCPMTEDPKQFEQIGIVNWGVGCKEKNVP 267

Human   407 GVYTRVSHFLPWIRSHTKE 425
            ..||.|..|.|||....||
  Fly   268 ATYTDVFEFKPWIVQQIKE 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		6/17 (35%)
		Tryp_SPc	179..422	CDD:238113	78/254 (31%)
CG31827	NP_723923.1	Tryp_SPc	50..283	CDD:238113	77/249 (31%)
CG31827	NP_723923.1	Tryp_SPc	50..280	CDD:214473	75/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910