DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG31205

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_001287432.1	Gene:	CG31205 / 318626	FlyBaseID:	FBgn0051205	Length:	274	Species:	Drosophila melanogaster

Alignment Length:	253	Identity:	65/253 - (25%)
Similarity:	98/253 - (38%)	Gaps:	48/253 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   191 PWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFE 255
            ||...|....:.||.|.:|.|.||....|::|.||......:..|.|..|.|. :||.
  Fly    50 PWVVRIVGVTKDGSNTLLCTGILIDSRRVVTAAHCVSKDESESIYGVVFGDSD-SSNI------- 106

Human   256 VENLI----LHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSM---------YNDP 307
              ||:    :|.|||....  .||:|:::: :||   ...|..:|.|||||:         .|..
  Fly   107 --NLVSAVTVHPDYSPRKF--ENDLAIIEL-TKE---VVFSDLVQPICLPSVSEMVPGSETSNSK 163

Human   308 QFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSC 372
            ......|...|.:.:|......:::|||..| |..:||   |...:....:::|.   ..:....
  Fly   164 LIVAGLEGPSFDRRHSATQRLDKRIKMTYTK-IDSKEC---HEKQARFPEELICG---HTERSPL 221

Human   373 QGD-----SGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE 425
            .|.     ||.|      .:..|.||...|...:..|..| |..:...|.||..::.:
  Fly   222 SGSALTEASGTP------RQFHLLGIAVAGFFSSDLDHQG-YLNIRPHLDWISKNSSK 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177
		Tryp_SPc	179..422	CDD:238113	65/248 (26%)
CG31205	NP_001287432.1	Tryp_SPc	44..>168	CDD:304450	39/133 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910