DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PLAU and CG32755

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	277	Identity:	102/277 - (36%)
Similarity:	141/277 - (50%)	Gaps:	48/277 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   167 QCGQKT-------LRPRFKIIGGEFTTIENQPWFA-----AIYRRHRGGSVTYVCGGSLISPCWV 219
            |.||.|       :.|  ||:||...||:..|:..     :|:.||.|  :.:||||::||...|
  Fly    21 QIGQPTATASPFVILP--KIVGGYTVTIDQVPFQVSVRRRSIHERHYG--LGHVCGGAVISQRVV 81

Human   220 ISATHCF-------IDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIA 277
            .||.||:       :.|...|.|:|..|.|.::...:...::.|:.::.||||:..||  .||||
  Fly    82 CSAAHCYAINTSVPLVYRDPELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNGSTL--ENDIA 144

Human   278 LLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFG----KENSTDYLYPEQLKMTVVK 338
            ||.:   .|.....|..::.|  |.....|:.||:|.|.|:|    ||.|.      .|:...|.
  Fly   145 LLFL---NGFIPWESPGVRAI--PLAIKAPEEGTTCLIHGWGKVTMKEKSA------SLQQAPVP 198

Human   339 LISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALK 403
            :::...||..:    ::....:||...|...|:|||||||||:|  .||  |.||:|||.|||..
  Fly   199 ILNKELCQVIY----KLPASQMCAGFLQGGIDACQGDSGGPLIC--DGR--LAGIISWGVGCADP 255

Human   404 DKPGVYTRVSHFLPWIR 420
            ..|||||.|||||.|||
  Fly   256 GYPGVYTNVSHFLKWIR 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		5/16 (31%)
		Tryp_SPc	179..422	CDD:238113	96/258 (37%)
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	94/256 (37%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	96/258 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910