DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLAU and CG32523

DIOPT Version :9

Sequence 1:NP_002649.2 Gene:PLAU / 5328 HGNCID:9052 Length:431 Species:Homo sapiens
Sequence 2:NP_728401.1 Gene:CG32523 / 318071 FlyBaseID:FBgn0052523 Length:262 Species:Drosophila melanogaster


Alignment Length:308 Identity:83/308 - (26%)
Similarity:127/308 - (41%) Gaps:57/308 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   132 WCYVQVGLKLL---VQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWF 193
            |..:...|.||   ||..:..|.|..:..|:             :.||  |:||   ....|..|
  Fly     2 WTTLWTVLLLLLCGVQVILGQDVAQNQSESA-------------IEPR--IVGG---IKAKQGQF 48

Human   194 A-AIYRRHRGGSVTYVCGGSLISPCWVISATHCF---IDYPKKEDYIVYLGRSRLNSNTQGEMKF 254
            . .|..|.||   .:.|||.:||...||:|.||.   .|....:.:.:..|...|:|:   .::.
  Fly    49 PHQISLRLRG---EHYCGGVIISATHVITAGHCVKHGNDVVPADLWSIQAGSLLLSSD---GVRI 107

Human   255 EVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQP---SRTIQTICLPSMYNDPQFGTSCEIT 316
            .|..:|:|.:|:.   ..|||:|:|:::|       |   ...|..|.|.:  .||....:.:|:
  Fly   108 PVAEVIMHPNYAT---GGHNDLAVLRLQS-------PLTFDANIAAIQLAT--EDPPNCVAVDIS 160

Human   317 GFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLV 381
            |:|.......| .:.|....|..||...|:...|  |.:...|:|....: .:.:|.||||||  
  Fly   161 GWGNIAEKGPL-SDSLLFVQVTSISRGACRWMFY--SRLPETMICLLHSK-NSGACYGDSGGP-- 219

Human   382 CSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGL 429
            .:..|::.....:..|.||. :..|..|.|:|....||    .|:.||
  Fly   220 ATYGGKVVGLASLLLGGGCG-RAAPDGYLRISKVRAWI----AEKAGL 262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLAUNP_002649.2 Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250 34..57
KR 67..152 CDD:238056 7/22 (32%)
Connecting peptide 152..177 3/24 (13%)
Tryp_SPc 179..422 CDD:238113 69/249 (28%)
CG32523NP_728401.1 Tryp_SPc 36..256 CDD:214473 68/249 (27%)
Tryp_SPc 37..219 CDD:238113 57/206 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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