DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG32376

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_729271.1	Gene:	CG32376 / 318002	FlyBaseID:	FBgn0052376	Length:	291	Species:	Drosophila melanogaster

Alignment Length:	249	Identity:	76/249 - (30%)
Similarity:	127/249 - (51%)	Gaps:	34/249 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRS 242
            :|:.|:.......|:..::   |..|  .:|||..:|:..|:::|.|||...|:|  |.|
  Fly    65 RIVNGKRIPCTEAPFQGSL---HYEG--YFVCGCVIINKIWILTAHHCFFGPPEK--YTV----- 117

Human   243 RLNSNTQ---GEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKE--GRCAQPSRTIQTICLPS 302
            |:.|:.|   |::: .|:.::....|:..|:.|  |:|::|::|..  |:|.:|      :.|||
  Fly   118 RVGSDQQRRGGQLR-HVKKIVALAAYNDYTMRH--DLAMMKLKSPVYFGKCVRP------VKLPS 173

Human   303 MYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPH-YYGSEVTTKMLCAADPQ 366
            . ...:|.....::|:|..::........|:...:..|...:||:.: ..|.::...|:||:  :
  Fly   174 T-KTTKFPKKFVVSGWGITSANAQNVQRYLRRVQIDYIKRSKCQKMYKKAGLKIYKDMICAS--R 235

Human   367 WKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR 420
            ...|||.|||||||.    .|..|.||||||.|||.|:.||||.....::|||:
  Fly   236 TNKDSCSGDSGGPLT----SRGVLYGIVSWGIGCANKNYPGVYVNCKRYVPWIK 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177
		Tryp_SPc	179..422	CDD:238113	76/248 (31%)
CG32376	NP_729271.1	Tryp_SPc	65..284	CDD:214473	74/246 (30%)
CG32376	NP_729271.1	Tryp_SPc	66..287	CDD:238113	76/248 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910