DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG6048

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster

Alignment Length:	285	Identity:	100/285 - (35%)
Similarity:	141/285 - (49%)	Gaps:	52/285 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   171 KTLRPRF-----KIIGGEFTTIENQPWFAAIYRRHRGG-----------SVTYVCGGSLISPCWV 219
            |.:||||     :||.|...::.        ..||:.|           ...::||||||.|.||
  Fly    33 KAIRPRFNADPGRIINGTEASLG--------ATRHQVGIRKALNDGYFFGTGHLCGGSLIRPGWV 89

Human   220 ISATHCFID-------YPKKEDYIVYLGR-SRLN-SNTQGEMKFEVENLILHKDYSADTLAHHND 275
            ::|.|||:|       :..||::||.:|. .|.| :||   :.|.:|..|:..| ..|...:..|
  Fly    90 LTAAHCFVDQIIYDGTFVPKEEFIVVMGNLDRYNRTNT---LTFTIEERIMQLD-KFDLSTYDKD 150

Human   276 IALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTV-VKL 339
            ||||.:   .|.......||:.|.| :.:..|: |..|::||:|   :|:..|...:.||| |.:
  Fly   151 IALLML---NGTVPTGHPTIRPIAL-NRFAIPE-GVVCQVTGWG---NTEDGYVSDILMTVDVPM 207

Human   340 ISHRECQQPHYYGSEVTTKMLCAADPQ-WKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALK 403
            ||...|......|..:...|:||...: .:.|:|.|||||||||..:    |.|:||||..|||.
  Fly   208 ISEEHCINDSDLGHLIQPGMICAGYLEVGEKDACAGDSGGPLVCQSE----LAGVVSWGIQCALP 268

Human   404 DKPGVYTRVSHFLPWIRSHTKEENG 428
            ..|||||.||::..||..: ..|||
  Fly   269 RLPGVYTEVSYYYDWILQN-MGENG 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		3/5 (60%)
		Tryp_SPc	179..422	CDD:238113	92/264 (35%)
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	90/262 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910