DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG33459

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_995855.2	Gene:	CG33459 / 2768847	FlyBaseID:	FBgn0053459	Length:	284	Species:	Drosophila melanogaster

Alignment Length:	278	Identity:	77/278 - (27%)
Similarity:	120/278 - (43%)	Gaps:	52/278 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   164 LKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID 228
            |:..|||...|.|  |.||....:.:.||.|.::..     :.::||||||:..:|::|.||.:.
  Fly    25 LEPNCGQIPFRMR--IFGGMDAGLVSTPWMAFLHNH-----LQFLCGGSLITSEFVLTAAHCVMP 82

Human   229 YPKKEDYIVYLGR-------SRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEG 286
            .||  :..|.||.       ..:|...: ..::.|..:..|..|.  ::|.: ||||||:    .
  Fly    83 TPK--NLTVRLGEYDWTRQMDSINPKHR-HREYMVTRIYTHPSYR--SIAAY-DIALLKL----N 137

Human   287 RCAQPSRTIQTIC--LPSMYND--------PQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 341
            :..:.:..|:.||  ||..:::        ..|    .:||:|...:..  ..:.|:...:..|.
  Fly   138 QTVEYTVAIRPICLVLPENFHEWYWLVDSVEDF----TLTGWGATKTEP--VSQVLQSANLTQID 196

Human   342 HRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCS-LQGRMTL---TGIVSWG-RGCA 401
            ...|..  .||..|....:||...  |:.:|.||||.||... :..|..:   .||||.| :.|
  Fly   197 RGTCHD--RYGHSVDHTHICAGSS--KSFACVGDSGSPLAMKVVHNRRYIHAQVGIVSRGPKNC- 256

Human   402 LKDKPGVYTRVSHFLPWI 419
              |...|:|.|..|..||
  Fly   257 --DGVTVFTNVVSFTEWI 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		5/12 (42%)
		Tryp_SPc	179..422	CDD:238113	71/263 (27%)
CG33459	NP_995855.2	Tryp_SPc	37..272	CDD:214473	70/264 (27%)
CG33459	NP_995855.2	Tryp_SPc	38..272	CDD:238113	69/261 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910