DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG30088

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_725488.3	Gene:	CG30088 / 246447	FlyBaseID:	FBgn0050088	Length:	281	Species:	Drosophila melanogaster

Alignment Length:	318	Identity:	87/318 - (27%)
Similarity:	132/318 - (41%)	Gaps:	76/318 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   133 CYV---QVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFA 194
            |.|   ||....|:..|.|                .::....|     :|:.|:...:::.|:.|
  Fly    17 CLVLQEQVAANFLIPSCGV----------------SYESNVAT-----RIVRGKEAMLKSAPFMA 60

Human   195 AIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRL--NSNTQG---EMKF 254
            .:|.     |....|||::||..::::|.||...|.|     |.||...:  |.:.||   ....
  Fly    61 YLYY-----SSEIHCGGTIISSRYILTAAHCMRPYLK-----VRLGEHDITRNPDCQGGSCSPPA 115

Human   255 EVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL-------PSMYNDPQFGTS 312
            |..:::|...|........|||||||:    .|..:.:..||.|||       |:::....||..
  Fly   116 EEFDIVLATKYKRFDRFLANDIALLKL----SRNIRFNVHIQPICLILNPAAAPNVHEFQAFGWG 176

Human   313 CEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSG 377
                    :..|:: ....|:.||:....:|.|:.  .....:|...||....  .:|:|.||||
  Fly   177 --------QTETNH-SANVLQTTVLTRYDNRHCRS--VLSMPITINQLCVGFQ--GSDTCSGDSG 228

Human   378 GPLVCSLQ----GRMTLTGIVSWGRGCALKDK---PGVYTRVSHFLPWIRSHTKEENG 428
            ||||..:.    .|....||||:|     .||   |||||.|.:::.||| :..:.||
  Fly   229 GPLVTKVNYDGVWRYLQLGIVSFG-----DDKCQSPGVYTYVPNYIRWIR-YVMQSNG 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	7/21 (33%)
		Connecting peptide	152..177		1/24 (4%)
		Tryp_SPc	179..422	CDD:238113	77/261 (30%)
CG30088	NP_725488.3	Tryp_SPc	44..272	CDD:214473	74/259 (29%)
CG30088	NP_725488.3	Tryp_SPc	45..273	CDD:238113	75/259 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910