DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAT and gammaTry

DIOPT Version :9

Sequence 1:	NP_000921.1	Gene:	PLAT / 5327	HGNCID:	9051	Length:	562	Species:	Homo sapiens
Sequence 2:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster

Alignment Length:	256	Identity:	81/256 - (31%)
Similarity:	120/256 - (46%)	Gaps:	31/256 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   307 PQF--RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLT 369
            ||.  ||.||....|:|.|||.::    :||....  |||.:.||..|::||||.|. .....|.
  Fly    25 PQLDGRIVGGSATTISSFPWQISL----QRSGSHS--CGGSIYSSNVIVTAAHCLQS-VSASVLQ 82

Human   370 VILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPA 434
            :..|.:|....|   ..|.|..:..|:.::.:|..||||::::..    ....||.::.:.|  |
  Fly    83 IRAGSSYWSSGG---VTFSVSSFKNHEGYNANTMVNDIAIIKING----ALTFSSTIKAIGL--A 138

Human   435 DLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRC-TSQHLLNRTVTDNMLCAGDTRS 498
            .....:.....:||:|.....|.....:|:..:|.:...|:| :|.:.....:...|:||.
  Fly   139 SSNPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAA---- 199

Human   499 GGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDN 559
                |:..||||||||||||  :.|  .|||::|||.||...:.||||..|.....|:..|
  Fly   200 ----ASGKDACQGDSGGPLV--SGG--VLVGVVSWGYGCAYSNYPGVYADVAALRSWVISN 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:306546
		Tryp_SPc	313..559	CDD:238113	76/246 (31%)
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	77/246 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910