Protein Alignment PLAT and CG6048

DIOPT Version :10

• Sequence 1: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Sequence 2: NP_572282.1
• Gene: CG6048 / 31528
• FlyBaseID: FBgn0029827
• Length: 362
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 88/279 - (31%)
• Similarity: 130/279 - (46%)
• Gaps: 50/279 - (17%)

Human   306 QPQF-----RIKGGLFADIASHPWQAAIFAKHRRSPGERF------LCGGILISSCWILSAAHCF 359
            :|:|     ||..|..|.:.:...|..|    |::..:.:      ||||.||...|:|:|||||
  Fly    36 RPRFNADPGRIINGTEASLGATRHQVGI----RKALNDGYFFGTGHLCGGSLIRPGWVLTAAHCF 96

Human   360 QERF-------PPHHLTVILG------RTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQ 411
            .::.       |.....|::|      ||..:....||:..:::|      ||..|||.|||||.
  Fly    97 VDQIIYDGTFVPKEEFIVVMGNLDRYNRTNTLTFTIEERIMQLDK------FDLSTYDKDIALLM 155

Human   412 LKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRC 476
            |   :.........:|.:.|  ....:|:...|:::|:|..|  ..:.|:.|....|.:.....|
  Fly   156 L---NGTVPTGHPTIRPIAL--NRFAIPEGVVCQVTGWGNTE--DGYVSDILMTVDVPMISEEHC 213

Human   477 TSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKD 541
            .:...|...:...|:|||....|.     .|||.|||||||||.::    |.|::|||:.|....
  Fly   214 INDSDLGHLIQPGMICAGYLEVGE-----KDACAGDSGGPLVCQSE----LAGVVSWGIQCALPR 269

Human   542 VPGVYTKVTNYLDWIRDNM 560
            :|||||:|:.|.|||..||
  Fly   270 LPGVYTEVSYYYDWILQNM 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005
		Tryp_SPc	313..559	CDD:238113	82/264 (31%)
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	82/264 (31%)