Protein Alignment PLAG1 and CG17801

DIOPT Version :10

• Sequence 1: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_650660.2
• Gene: CG17801 / 42144
• FlyBaseID: FBgn0038550
• Length: 381
• Species: Drosophila melanogaster
• Alignment Length: 183
• Identity: 49/183 - (26%)
• Similarity: 79/183 - (43%)
• Gaps: 13/183 - (7%)

Human     6 PGDLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCIQQDCT 70
            |.|::    .:.||..||   ..:..::..|..|.:.|.:...||.|...||||:.:.|  ..|.
  Fly   209 PEDVA----AENVPPAKR---TARKMQSLVCPKCGRVFKTPYNLKTHMVRHTGEKNFPC--TFCD 264

Human    71 KAFVSKYKLQRH-MATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKNYNTKL 134
            |.||:||..:.| ...|..|:..:||:|...|.......:|..........::|::|.|.:|||.
  Fly   265 KRFVTKYLARLHERVRHMGEQPFECNFCSATFFTSTAKSSHERIRHIRDLRYQCDQCTKRFNTKT 329

Human   135 GFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKS--HAGKSSGGVKEKKH 185
            ...:|..||:... ...|.:|...|.....|..|..|  |..::|..::.::|
  Fly   330 CLNKHKFLHSGLK-PFDCVICQINFARKATLRSHFDSVAHQKRASAILESEEH 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		6/23 (26%)
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84		24/78 (31%)
		Nuclear localization signal	22..25		2/2 (100%)
		C2H2 Zn finger	36..56	CDD:275368	6/19 (32%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		41/148 (28%)
		SFP1	<58..139	CDD:227516	23/81 (28%)
		C2H2 Zn finger	64..86	CDD:275368	8/22 (36%)
		zf-H2C2_2	79..101	CDD:463886	6/22 (27%)
		C2H2 Zn finger	94..114	CDD:275368	5/19 (26%)
		C2H2 Zn finger	123..143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	6/21 (29%)
		C2H2 Zn finger	187..207	CDD:275368
		C2H2 Zn finger	215..233	CDD:275368
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500
CG17801	NP_650660.2	zf-AD	9..76	CDD:462262
		zf-C2H2	231..252	CDD:395048	6/20 (30%)
		C2H2 Zn finger	232..252	CDD:275368	6/19 (32%)
		zf-H2C2_2	244..269	CDD:463886	11/26 (42%)
		C2H2 Zn finger	260..281	CDD:275368	8/22 (36%)
		C2H2 Zn finger	289..308	CDD:275368	5/18 (28%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..362	CDD:275368	4/15 (27%)