Protein Alignment PLAG1 and CG6813

DIOPT Version :10

• Sequence 1: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_001163590.1
• Gene: CG6813 / 41396
• FlyBaseID: FBgn0037923
• Length: 294
• Species: Drosophila melanogaster
• Alignment Length: 25
• Identity: 8/25 - (32%)
• Similarity: 13/25 - (52%)
• Gaps: 3/25 - (12%)

Human   141 QQLREKISQLGQKEVELQKARKELI 165
            :||.|   .||...:...::|.||:
  Fly    61 EQLME---YLGVYAIFYHRSRTELM 82

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84
		Nuclear localization signal	22..25
		C2H2 Zn finger	36..56	CDD:275368
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		8/25 (32%)
		SFP1	<58..139	CDD:227516
		C2H2 Zn finger	64..86	CDD:275368
		zf-H2C2_2	79..101	CDD:463886
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	123..143	CDD:275368	0/1 (0%)
		C2H2 Zn finger	152..172	CDD:275368	3/14 (21%)
		C2H2 Zn finger	187..207	CDD:275368
		C2H2 Zn finger	215..233	CDD:275368
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500
CG6813	NP_001163590.1	zf-AD	5..76	CDD:462262	5/17 (29%)
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	172..194	CDD:275368
		UFD2	<256..>294	CDD:227443
		C2H2 Zn finger	258..280	CDD:275368