Protein Alignment PLAG1 and Plag1

DIOPT Version :10

• Sequence 1: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_001008317.1
• Gene: Plag1 / 297804
• RGDID: 1305286
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 480/500 - (96%)
• Similarity: 490/500 - (98%)
• Gaps: 1/500 - (0%)

Human     1 MATVIPGDLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCI 65
            |||||||||||||||||.|||||||||:|||||||||||||||||||||||||:||||||||||.
  Rat     1 MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCT 65

Human    66 QQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKNY 130
            .||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
  Rat    66 HQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSY 130

Human   131 NTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCDRRFY 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat   131 NTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFY 195

Human   196 TRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNVSV 260
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
  Rat   196 TRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSV 260

Human   261 PIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQSSGSAHQMITTLPLGMTCPIDMDTVH 325
            |||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
  Rat   261 PIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVH 325

Human   326 PSHHLSFKYPFSSTSYAISIPEKEQPLKGEIESYLMELQGGVPSSSQDSQASSSSKLGLDPQIGS 390
            |||||:||.||||||||||||||||||||||||||||||||.||||||||| |||||||:||.||
  Rat   326 PSHHLAFKCPFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQA-SSSKLGLEPQSGS 389

Human   391 LDDGAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQEEAHSSVSQ 455
            .|||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||
  Rat   390 PDDGAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHSSVSQ 454

Human   456 LPPQTQDLQDPANTIGLGSLHSLSAAFTSSLSTSTTLPRFHQAFQ 500
            ||.|||||||||||:|||||||||||||||||:||||||||||||
  Rat   455 LPTQTQDLQDPANTVGLGSLHSLSAAFTSSLSSSTTLPRFHQAFQ 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		26/28 (93%)
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84		76/81 (94%)
		Nuclear localization signal	22..25		2/2 (100%)
		C2H2 Zn finger	36..56	CDD:275368	18/19 (95%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		195/200 (98%)
		SFP1	<58..139	CDD:227516	77/80 (96%)
		C2H2 Zn finger	64..86	CDD:275368	19/21 (90%)
		zf-H2C2_2	79..101	CDD:463886	21/21 (100%)
		C2H2 Zn finger	94..114	CDD:275368	19/19 (100%)
		C2H2 Zn finger	123..143	CDD:275368	18/19 (95%)
		C2H2 Zn finger	152..172	CDD:275368	19/19 (100%)
		C2H2 Zn finger	187..207	CDD:275368	18/19 (95%)
		C2H2 Zn finger	215..233	CDD:275368	17/17 (100%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500		243/256 (95%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384		134/140 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388		19/22 (86%)
		Massively activates transcription	385..500		107/114 (94%)
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		29/31 (94%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		76/81 (94%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		2/2 (100%)
		C2H2 Zn finger	36..56	CDD:275368	18/19 (95%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		195/200 (98%)
		SFP1	<58..139	CDD:227516	77/80 (96%)
		C2H2 Zn finger	64..86	CDD:275368	19/21 (90%)
		zf-H2C2_2	79..101	CDD:463886	21/21 (100%)
		C2H2 Zn finger	94..114	CDD:275368	19/19 (100%)
		C2H2 Zn finger	123..143	CDD:275368	18/19 (95%)
		C2H2 Zn finger	152..172	CDD:275368	19/19 (100%)
		C2H2 Zn finger	187..207	CDD:275368	18/19 (95%)
		C2H2 Zn finger	215..233	CDD:275368	17/17 (100%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		243/256 (95%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		134/140 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..400		31/36 (86%)
		Massively activates transcription. /evidence=ECO:0000250	384..499		107/114 (94%)