DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKP2 and p120ctn

DIOPT Version :10

Sequence 1:NP_004563.2 Gene:PKP2 / 5318 HGNCID:9024 Length:881 Species:Homo sapiens
Sequence 2:NP_001036444.1 Gene:p120ctn / 3355143 FlyBaseID:FBgn0260799 Length:781 Species:Drosophila melanogaster


Alignment Length:794 Identity:209/794 - (26%)
Similarity:339/794 - (42%) Gaps:143/794 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   136 VEERSLRHPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPPRYAR--SE 198
            :|.|||:|.|..|.::..........||.  ..:.:||.|...::.:...|.....|.|..  :.
  Fly     1 MEARSLKHSLIGLNMNSTHINMDLSLTHE--PANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTG 63

Human   199 IVGVSRAGTTSRQRHFDTYHRQYQHGSVSDTVFDSIPANPALLTYPRPGTSR--SMGNLLEKENY 261
            :..:::......|...:|       .|..:::       |.:..:|...|.|  ..|...:...|
  Fly    64 VGAITKVAPHCSQNKIET-------NSTDNSI-------PDIENHPLATTVRYVQAGQYEDTSEY 114

Human   262 LTAGLTVG-----QVRPLVP-----------LQPVTQNRASRSSWHQSSFHSTRTLREAGPSVAV 310
            ..||||.|     ....:||           :|..|   :|...:....|:....    |.....
  Fly   115 GVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTT---SSIKPFSGRPFNDNIN----GAEAVA 172

Human   311 DSSGR----RAHLTVGQAAAGGSGNLLTERSTFTDSQLGNADMEM---------TLERAVSMLEA 362
            ||..|    .|...:.|.|. .|.|.:.:|....|..:..::.::         .|...:|.|..
  Fly   173 DSQCRTFKSSAEFKLPQFAM-SSINTVPQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSN 236

Human   363 DHMLPSRISA-AATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVF-- 424
            .   .|.|.| ||.::||.|:.....::|...|.||..|::||...:.::.:..|||||||.:  
  Fly   237 P---SSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGR 298

Human   425 EDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITDHTVNLRSRNGWPGAVAHACNPSTLGGQGG 489
            ::::||..:....|:..|:.:|.::::.|.|:.:|                              
  Fly   299 QNDENKRGIKNAGGIAALVHLLCRSQETEVKELVT------------------------------ 333

Human   490 RITRSGVRDQPDQHGLLWNLSSNDKLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDI 554
                          |:|||:||.:.||..:|.|||:.:..::|.|.|||   |...........:
  Fly   334 --------------GVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGW---DAVCCGETCFSTV 381

Human   555 FYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLE 619
            |.|.:|.|||:||||...|..:|.|:.|::.|::.||.:|......:|..|||||||.||||:.:
  Fly   382 FRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQ 446

Human   620 AELPEKYSQNIYIQNRNIQTDNNK--SIGCFGSRSRK-------------VKEQYQDVPMPEEKS 669
            ......|.::.:|....:...::|  ::||||:..:|             :...|....:...|.
  Fly   447 EVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKL 511

Human   670 NPKGVEWLWHSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTVVQKESGLQHT 734
            | ||.|.||...|::.||||:.......|.||:.||:|||:|... .|:...:..|:||.||...
  Fly   512 N-KGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYW-QPSIDIRATVRKEKGLPIL 574

Human   735 RKMLHVGDPSVKKTAISLLRNLS---RNLSLQNEIAKETLPDLVSIIP------DTVPSTDLLIE 790
            .::|.:....|.....:.||||:   ||..|   |.|..:.|||..:|      |...|.|    
  Fly   575 VELLRMEVDRVVCAVATALRNLAIDQRNKEL---IGKYAMRDLVQKLPSGNVQHDQNTSDD---- 632

Human   791 TTASACYTLNNIIQNSYQNARDLLNTGGIQKIMAISAGDAYASNKASKAASVLLYSLWAHTELHH 855
            |..:...|:|.:|:.:.:.:|.||::|||.::|.|:......::...|.||.:||::|.|.||..
  Fly   633 TITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRD 697

Human   856 AYKKAQFKKTDFVN 869
            .|||..:|:.|||:
  Fly   698 VYKKNGWKEQDFVS 711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKP2NP_004563.2 Required for binding to single-stranded DNA. /evidence=ECO:0000269|PubMed:20613778 1..360 48/256 (19%)
Required for interaction with influenza A virus RNA polymerase subunit PB1. /evidence=ECO:0000269|PubMed:28169297 1..348 46/235 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..314 5/31 (16%)
ARM 1 341..383 12/51 (24%)
ARM 2 385..424 14/38 (37%)
armadillo repeat 388..424 CDD:293788 14/35 (40%)
ARM 3 427..467 8/39 (21%)
armadillo repeat 430..460 CDD:293788 6/29 (21%)
ARM 4 571..616 18/44 (41%)
ARM 5 671..711 18/39 (46%)
ARM 6 719..758 11/41 (27%)
armadillo repeat 724..756 CDD:293788 9/31 (29%)
ARM 7 763..804 12/46 (26%)
armadillo repeat 764..804 CDD:293788 12/45 (27%)
ARM 8 807..849 13/41 (32%)
p120ctnNP_001036444.1 armadillo repeat 227..252 CDD:293788 9/27 (33%)
Arm 256..295 CDD:425727 13/38 (34%)
armadillo repeat 260..296 CDD:293788 14/35 (40%)
ARM 300..341 CDD:214547 12/84 (14%)
armadillo repeat 304..339 CDD:293788 10/78 (13%)
armadillo repeat 347..392 CDD:293788 15/47 (32%)
armadillo repeat 515..556 CDD:293788 17/41 (41%)
Arm 516..552 CDD:425727 16/35 (46%)
ARM 560..597 CDD:214547 10/36 (28%)
armadillo repeat 562..596 CDD:293788 9/33 (27%)
armadillo repeat 601..641 CDD:293788 13/46 (28%)

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