DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKP2 and p120ctn

DIOPT Version :9

Sequence 1:	NP_004563.2	Gene:	PKP2 / 5318	HGNCID:	9024	Length:	881	Species:	Homo sapiens
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	794	Identity:	209/794 - (26%)
Similarity:	339/794 - (42%)	Gaps:	143/794 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   136 VEERSLRHPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPPRYAR--SE 198
            :|.|||:|.|..|.::..........||.  ..:.:||.|...::.:...|.....|.|..  :.
  Fly     1 MEARSLKHSLIGLNMNSTHINMDLSLTHE--PANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTG 63

Human   199 IVGVSRAGTTSRQRHFDTYHRQYQHGSVSDTVFDSIPANPALLTYPRPGTSR--SMGNLLEKENY 261
            :..:::......|...:|       .|..:::       |.:..:|...|.|  ..|...:...|
  Fly    64 VGAITKVAPHCSQNKIET-------NSTDNSI-------PDIENHPLATTVRYVQAGQYEDTSEY 114

Human   262 LTAGLTVG-----QVRPLVP-----------LQPVTQNRASRSSWHQSSFHSTRTLREAGPSVAV 310
            ..||||.|     ....:||           :|..|   :|...:....|:....    |.....
  Fly   115 GVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTT---SSIKPFSGRPFNDNIN----GAEAVA 172

Human   311 DSSGR----RAHLTVGQAAAGGSGNLLTERSTFTDSQLGNADMEM---------TLERAVSMLEA 362
            ||..|    .|...:.|.|. .|.|.:.:|....|..:..::.::         .|...:|.|..
  Fly   173 DSQCRTFKSSAEFKLPQFAM-SSINTVPQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSN 236

Human   363 DHMLPSRISA-AATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVF-- 424
            .   .|.|.| ||.::||.|:.....::|...|.||..|::||...:.::.:..|||||||.:
  Fly   237 P---SSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGR 298

Human   425 EDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITDHTVNLRSRNGWPGAVAHACNPSTLGGQGG 489
            ::::||..:....|:..|:.:|.::::.|.|:.:|
  Fly   299 QNDENKRGIKNAGGIAALVHLLCRSQETEVKELVT------------------------------ 333

Human   490 RITRSGVRDQPDQHGLLWNLSSNDKLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDI 554
                          |:|||:||.:.||..:|.|||:.:..::|.|.|||   |...........:
  Fly   334 --------------GVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGW---DAVCCGETCFSTV 381

Human   555 FYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLE 619
            |.|.:|.|||:||||...|..:|.|:.|::.|::.||.:|......:|..|||||||.||||:.:
  Fly   382 FRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQ 446

Human   620 AELPEKYSQNIYIQNRNIQTDNNK--SIGCFGSRSRK-------------VKEQYQDVPMPEEKS 669
            ......|.::.:|....:...::|  ::||||:..:|             :...|....:...|.
  Fly   447 EVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKL 511

Human   670 NPKGVEWLWHSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTVVQKESGLQHT 734
            | ||.|.||...|::.||||:.......|.||:.||:|||:|... .|:...:..|:||.||...
  Fly   512 N-KGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYW-QPSIDIRATVRKEKGLPIL 574

Human   735 RKMLHVGDPSVKKTAISLLRNLS---RNLSLQNEIAKETLPDLVSIIP------DTVPSTDLLIE 790
            .::|.:....|.....:.||||:   ||..|   |.|..:.|||..:|      |...|.|
  Fly   575 VELLRMEVDRVVCAVATALRNLAIDQRNKEL---IGKYAMRDLVQKLPSGNVQHDQNTSDD---- 632

Human   791 TTASACYTLNNIIQNSYQNARDLLNTGGIQKIMAISAGDAYASNKASKAASVLLYSLWAHTELHH 855
            |..:...|:|.:|:.:.:.:|.||::|||.::|.|:......::...|.||.:||::|.|.||..
  Fly   633 TITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRD 697

Human   856 AYKKAQFKKTDFVN 869
            .|||..:|:.|||:
  Fly   698 VYKKNGWKEQDFVS 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKP2	NP_004563.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314		5/31 (16%)
		ARM 1	341..383		12/51 (24%)
		ARM	350..467	CDD:237987	33/128 (26%)
		ARM 2	385..424		14/38 (37%)
		armadillo repeat	388..424	CDD:293788	14/35 (40%)
		ARM 3	427..467		8/39 (21%)
		armadillo repeat	430..460	CDD:293788	6/29 (21%)
		ARM 4	571..616		18/44 (41%)
		ARM 5	671..711		18/39 (46%)
		ARM	675..804	CDD:237987	44/137 (32%)
		ARM 6	719..758		11/41 (27%)
		armadillo repeat	724..756	CDD:293788	9/31 (29%)
		ARM 7	763..804		12/46 (26%)
		armadillo repeat	764..804	CDD:293788	12/45 (27%)
		ARM 8	807..849		13/41 (32%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	37/160 (23%)
		armadillo repeat	227..252	CDD:293788	9/27 (33%)
		armadillo repeat	260..296	CDD:293788	14/35 (40%)
		armadillo repeat	304..339	CDD:293788	10/78 (13%)
		ARM	307..442	CDD:237987	51/181 (28%)
		armadillo repeat	347..392	CDD:293788	15/47 (32%)
		armadillo repeat	515..556	CDD:293788	17/41 (41%)
		ARM	516..643	CDD:237987	43/134 (32%)
		armadillo repeat	562..596	CDD:293788	9/33 (27%)
		armadillo repeat	601..641	CDD:293788	13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149481
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800