DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKP2 and Pkp2

DIOPT Version :9

Sequence 1:	NP_004563.2	Gene:	PKP2 / 5318	HGNCID:	9024	Length:	881	Species:	Homo sapiens
Sequence 2:	NP_001093969.1	Gene:	Pkp2 / 287925	RGDID:	1306533	Length:	795	Species:	Rattus norvegicus

Alignment Length:	881	Identity:	664/881 - (75%)
Similarity:	715/881 - (81%)	Gaps:	86/881 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAPGAPAEYGYIRTVLGQQILGQLDSSSLALPSEAKLKLAGSSGRGGQTVKSLRIQEQVQQTLA 65
            ||.||:..|.|||||||||||||.||||||||||||:|:||||||||....:|.|||||||||||
  Rat     1 MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTLA 65

Human    66 RKGRSSVGNGNLHRTSSVPEYVYNLHLVENDFVGGRSPVPKTYDMLKAGTTATYEGRWGRGTAQY 130
            |:|||||..||||||||||||||.||||||||||.:||..:.|||||||.||||..|||||||||
  Rat    66 RRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKAGVTATYGSRWGRGTAQY 130

Human   131 SSQKSVEERSLRHPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPPRYA 195
            ||||||||||.|.||||||||||||||||||.||:|||:.||      |.....|..|   ||||
  Rat   131 SSQKSVEERSWRQPLRRLEISPDSSPERAHYGHSEYQYAWRS------HVVPGGRLTL---PRYA 186

Human   196 RSEIVGVSRAGTTSRQRHFDTYHRQYQHGSVSDTVFDSIPANPALLTYPRPGTSRSMGNLLEKEN 260
            ||||:|:.:.||..|....         |||||.|||:.|.||.:.|:| ||||.|.|:|||:..
  Rat   187 RSEILGLRQTGTARRAPGC---------GSVSDAVFDNGPLNPTIPTHP-PGTSHSAGSLLEETT 241

Human   261 YLTAGLTVGQVRPLVPLQPVTQNRASRSSWHQSSFHSTRTLREAGPSVAVDSSGRRAHLTVGQAA 325
                 :.|.|.|    .|.: |:||.||||.:||.||  ||||:|          |...|.||||
  Rat   242 -----VRVSQAR----FQGL-QSRAGRSSWPRSSVHS--TLRESG----------RMLPTAGQAA 284

Human   326 AGGSGNLLTERSTFTDSQLGNADMEMTLERAVSMLEADHMLPSRISAAATFIQHECFQKSEARKR 390
            . |||:...:||.|.||||||||:||||||||:||:|||:..|:|||||||||||.|||||||||
  Rat   285 V-GSGDAHRDRSAFADSQLGNADLEMTLERAVNMLDADHVPLSKISAAATFIQHESFQKSEARKR 348

Human   391 VNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETK 455
            ||||:||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   349 VNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETK 413

Human   456 KQITDHTVNLRSRNGWPGAVAHACNPSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNLMI 520
            ||||                                            ||||||||:||||:|||
  Rat   414 KQIT--------------------------------------------GLLWNLSSSDKLKHLMI 434

Human   521 TEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDS 585
            |||||||||::||||||||||||||||||||||||||||||||||||||.||||.||||||||||
  Rat   435 TEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDS 499

Human   586 LVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGS 650
            |||||||||||||||||||||||||||||||||||||||||||:||:|||||||::|||||||||
  Rat   500 LVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGS 564

Human   651 RSRKVKEQYQDVPMPEEKSNPKGVEWLWHSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGP 715
            |||||||||||.|||||:|:|:|:|||||||||||||||||||.|||||||||||||||||||||
  Rat   565 RSRKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGP 629

Human   716 MPTSVAQTVVQKESGLQHTRKMLHVGDPSVKKTAISLLRNLSRNLSLQNEIAKETLPDLVSIIPD 780
            :|||||:.|||||:||||||||||||||||||||:||||||||||||||||||||||||||||||
  Rat   630 IPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPD 694

Human   781 TVPSTDLLIETTASACYTLNNIIQNSYQNARDLLNTGGIQKIMAISAGDAYASNKASKAASVLLY 845
            |||||||||||||||||||||::|||||||||||||||:||||.||.|:.||.||||||||||||
  Rat   695 TVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLY 759

Human   846 SLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLKD 881
            |||||||||:||||||||||||||||||||.|||||
  Rat   760 SLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKP2	NP_004563.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314		16/31 (52%)
		ARM 1	341..383		33/41 (80%)
		ARM	350..467	CDD:237987	101/116 (87%)
		ARM 2	385..424		36/38 (95%)
		armadillo repeat	388..424	CDD:293788	33/35 (94%)
		ARM 3	427..467		33/39 (85%)
		armadillo repeat	430..460	CDD:293788	29/29 (100%)
		ARM 4	571..616		43/44 (98%)
		ARM 5	671..711		36/39 (92%)
		ARM	675..804	CDD:237987	121/128 (95%)
		ARM 6	719..758		34/38 (89%)
		armadillo repeat	724..756	CDD:293788	29/31 (94%)
		ARM 7	763..804		39/40 (98%)
		armadillo repeat	764..804	CDD:293788	38/39 (97%)
		ARM 8	807..849		35/41 (85%)
Pkp2	NP_001093969.1	ARM	308..425	CDD:237987	107/160 (67%)
		armadillo repeat	311..338	CDD:293788	20/26 (77%)
		armadillo repeat	346..382	CDD:293788	33/35 (94%)
		armadillo repeat	388..423	CDD:293788	34/78 (44%)
		armadillo repeat	435..479	CDD:293788	41/43 (95%)
		ARM	589..718	CDD:237987	121/128 (95%)
		armadillo repeat	636..670	CDD:293788	29/33 (88%)
		armadillo repeat	678..716	CDD:293788	37/37 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	709	1.000	Domainoid score	I3489
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3364
Inparanoid	1	1.050	977	1.000	Inparanoid score	I5637
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37184
OrthoDB	1	1.010	-	-		D144301at32523
OrthoFinder	1	1.000	-	-		FOG0012003
OrthoInspector	1	1.000	-	-		oto132826
orthoMCL	1	0.900	-	-		OOG6_120558
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9854
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	15.480