DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKP1 and Pkp1

DIOPT Version :9

Sequence 1:	NP_000290.2	Gene:	PKP1 / 5317	HGNCID:	9023	Length:	747	Species:	Homo sapiens
Sequence 2:	NP_001300630.1	Gene:	Pkp1 / 18772	MGIID:	1328359	Length:	728	Species:	Mus musculus

Alignment Length:	749	Identity:	690/749 - (92%)
Similarity:	710/749 - (94%)	Gaps:	23/749 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHS 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHS 65

Human    66 NRGSMYDGLADNY-NYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRH 129
            ||||||||||||| ||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse    66 NRGSMYDGLADNYNNYGTTSRSSYFSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRH 130

Human   130 YPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQK 194
            ||||||.|.||||||||||||||||||||||||||||||||||||||.||||||.||||||||||
Mouse   131 YPRGSCATPGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGHKTTQNRCSFYSTCSGQK 195

Human   195 AIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDE 259
            |:||||||||||.|||||||:|||||||||||||||||||||||||||||||||||||||.||||
Mouse   196 AVKKCPVRPPSCTSKQDPVYVPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLCSQDE 260

Human   260 KYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Mouse   261 KYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTPNKLE 325

Human   325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDG 389
            ||||||||||||||||:|:.|||||||||||||||||||||||:|||||||.|||||||||||||
Mouse   326 TRRQNGIREAVSLLRRSGSTEIQKQLTGLLWNLSSTDELKEELVADALPVLTDRVIIPFSGWCDG 390

Human   390 NSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSL 454
            ||||||||||||||||||||||                     ||||||||||||||||||||||
Mouse   391 NSNMSREVVDPEVFFNATGCLR---------------------NLSSADAGRQTMRNYSGLIDSL 434

Human   455 MAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSD 519
            |||||||||||||||||||||||:||||||||||||||||||||||.|||||||||||||||:.|
Mouse   435 MAYVQNCVAASRCDDKSVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSSTGCFSNRGD 499

Human   520 KMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSS 584
            |||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||:
Mouse   500 KMMNNNYDCPLPEEETNPKGSSWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSN 564

Human   585 GMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTG 649
            |||||||:||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Mouse   565 GMSQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPVLHRVMGNQVFPEVTRLLTSHTG 629

Human   650 NTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-SPKAAEAARLLLSDMWS 713
            ||||||||||||||||||||.||||:||||||:|||||:.||||::| ||||||||||||||||:
Mouse   630 NTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLNNVFNLCRNTASSPKAAEAARLLLSDMWA 694

Human   714 SKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF 747
            |||||.|||||||||||:|.:||||:||||||||
Mouse   695 SKELQSVLRQQGFDRNMMGNIAGANNLRNFTSRF 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKP1	NP_000290.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..68		19/19 (100%)
		ARM	238..359	CDD:237987	115/120 (96%)
		armadillo repeat	239..272	CDD:293788	31/32 (97%)
		ARM 1	243..274		29/30 (97%)
		ARM 2	275..316		40/40 (100%)
		armadillo repeat	280..316	CDD:293788	35/35 (100%)
		ARM 3	317..359		37/41 (90%)
		armadillo repeat	322..357	CDD:293788	31/34 (91%)
		ARM 4	360..415		50/54 (93%)
		ARM 5	416..463		29/46 (63%)
		ARM 6	525..556		29/30 (97%)
		ARM	542..670	CDD:237987	124/127 (98%)
		ARM 7	557..603		43/45 (96%)
		armadillo repeat	589..624	CDD:293788	33/34 (97%)
		ARM 8	604..649		43/44 (98%)
		armadillo repeat	630..668	CDD:293788	37/37 (100%)
		ARM 9	650..713		55/63 (87%)
		armadillo repeat	677..707	CDD:293788	24/30 (80%)
Pkp1	NP_001300630.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..69		20/20 (100%)
		armadillo repeat	240..273	CDD:293788	31/32 (97%)
		ARM 1	244..275		29/30 (97%)
		ARM 2	276..317		40/40 (100%)
		ARM	277..317	CDD:214547	39/39 (100%)
		armadillo repeat	281..317	CDD:293788	35/35 (100%)
		ARM 3	318..360		37/41 (90%)
		ARM	319..360	CDD:214547	36/40 (90%)
		armadillo repeat	323..358	CDD:293788	31/34 (91%)
		ARM 4	361..412		48/50 (96%)
		armadillo repeat	365..416	CDD:293788	48/71 (68%)
		ARM 5	413..443		29/29 (100%)
		ARM 6	505..536		29/30 (97%)
		ARM 7	537..583		43/45 (96%)
		armadillo repeat	569..604	CDD:293788	33/34 (97%)
		ARM 8	584..629		43/44 (98%)
		armadillo repeat	610..648	CDD:293788	37/37 (100%)
		ARM 9	630..694		55/63 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83956528
Domainoid	1	1.000	688	1.000	Domainoid score	I3936
eggNOG	1	0.900	-	-		E1_KOG1048
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H253
Inparanoid	1	1.050	1390	1.000	Inparanoid score	I3461
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40646
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008035
OrthoInspector	1	1.000	-	-		oto117799
orthoMCL	1	0.900	-	-		OOG6_117501
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7757
SonicParanoid	1	1.000	-	-		X10315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.290