DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKP1 and pkp1

DIOPT Version :9

Sequence 1:	NP_000290.2	Gene:	PKP1 / 5317	HGNCID:	9023	Length:	747	Species:	Homo sapiens
Sequence 2:	XP_012809816.1	Gene:	pkp1 / 100496099	XenbaseID:	XB-GENE-949309	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	414/788 - (52%)
Similarity:	534/788 - (67%)	Gaps:	87/788 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 SPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRG 68
            ||||||||.|.|...:.|:||:|||:.::.|.||.|||:|||||||||.||:||.||.   ..:.
Frog     6 SPLKTALASEVFLWPNESSLAVPSDKCLRGGVSGDQRVKEQVMMTVKRHKSRSSTSSP---GYKS 67

Human    69 SMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRG 133
            |||:.:||..|....:.::.|||:|:.| |.||. |||||||  |.:|||||||.:||.:|....
Frog    68 SMYETVADYNNMNYNNNANQYSKYQSAN-SIGYQ-YNGTLKR--DQQRFSSYSQADNWGQHRHMS 128

Human   134 SCNTTGAGSDICFMQKIKASRSEPDLY-CDPRGTLRKGTLGSKGQKTTQNRY------------- 184
            ..:....|||..:.|.:|:|||||||. .|.|.|||:           ||:|
Frog   129 YASPLSPGSDFDYKQTLKSSRSEPDLTGPDVRATLRR-----------QNQYNQMQNQHHQQQRP 182

Human   185 ------SFYSTCSGQKAIKK----CPVRPPSCAS---------KQDPVYIPPISCN--------- 221
                  ||||..|.|:  ||    .|.|.||..|         :|...|......|
Frog   183 GRAHNSSFYSYHSTQQ--KKRGPMTPARTPSSLSTVQQQQQQQQQQHCYYTNAQRNESNFQNFNI 245

Human   222 -KDLSFGHSRASSKICSED-IECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVY 284
             |..::|.....|::.:.| .:..|:|:.:||:.|...|:|:|..||.||||.|||||:||..||
Frog   246 PKQDNYGTINVPSRMDTRDEFDAGGMTLDRAVELLGYPDDKFQMSGANYIQHACFQDENAKNLVY 310

Human   285 QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQ 349
            |..||.||::||:|||:|||||.|||||||||:::.|||||.::.|.|||||||:||.:.:||||
Frog   311 QSNGISKLINLLQSPNENVQQATAGALRNLVFKNSANKLETSQKGGTREAVSLLKRTSHPDIQKQ 375

Human   350 LTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRL 414
            ||||||||||:|:||:||:.:|||||.:||:||:|||.:.:.:....::|||||||||||||
Frog   376 LTGLLWNLSSSDQLKDELVKEALPVLNERVVIPYSGWSERSMSNQNCMLDPEVFFNATGCLR--- 437

Human   415 GMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479
                              ||||||.||:.|||..||:||||.|:|.|:|....||||||||.|:|
Frog   438 ------------------NLSSADVGRKAMRNCPGLVDSLMFYIQKCLANKCPDDKSVENCACIL 484

Human   480 HNLSYRLDAEVPTRYRQL-EYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWL 543
            |||||.||:|||.:|.|| |...|....:|::||||||||:|:.|||:..|||||:.||||:..|
Frog   485 HNLSYHLDSEVPNKYSQLDEQMYRLQQNDKTTTGCFSNKSEKLQNNNFQLPLPEEDANPKGAALL 549

Human   544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN 608
            .||.||||||:|:.:||||:|||||||||||||||||.||:||||:||||:||:|||.|||||||
Frog   550 SHSSAIRTYLSLLEQSKKDSTLEACAGALQNLTASKGQMSNGMSQIIGLKDKGIPQITRLLQSGN 614

Human   609 SDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673
            :|||::|:||||||||||.||:.|..|..|:|:|:|:..:|.|.||||||||||||:|||..::|
Frog   615 ADVVKAGSSLLSNMSRHPSLHKTMATQALPDVSRILSQSSGKTMNSEDILSSACYTMRNLAMAEP 679

Human   674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 738
            |:|||..|.::|.|::|:|:|.||||..||||:.|:|||:.:||||.|:|||.|::::|:|| :.
Frog   680 QIAKQNISGNLLGNLVNMCKSGASPKVGEAARVFLTDMWAQRELQGFLKQQGLDKSIMGSLA-ST 743

Human   739 SLRNFTSR 746
            :|||...|
Frog   744 ALRNTIPR 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKP1	NP_000290.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..68		10/19 (53%)
		ARM	238..359	CDD:237987	75/121 (62%)
		armadillo repeat	239..272	CDD:293788	14/33 (42%)
		ARM 1	243..274		14/30 (47%)
		ARM 2	275..316		29/40 (73%)
		armadillo repeat	280..316	CDD:293788	25/35 (71%)
		ARM 3	317..359		27/41 (66%)
		armadillo repeat	322..357	CDD:293788	24/34 (71%)
		ARM 4	360..415		30/54 (56%)
		ARM 5	416..463		20/46 (43%)
		ARM 6	525..556		19/30 (63%)
		ARM	542..670	CDD:237987	92/127 (72%)
		ARM 7	557..603		36/45 (80%)
		armadillo repeat	589..624	CDD:293788	26/34 (76%)
		ARM 8	604..649		27/44 (61%)
		armadillo repeat	630..668	CDD:293788	21/37 (57%)
		ARM 9	650..713		38/62 (61%)
		armadillo repeat	677..707	CDD:293788	16/29 (55%)
pkp1	XP_012809816.1	armadillo repeat	273..298	CDD:293788	11/24 (46%)
		Syo1_like	301..>506	CDD:240521	135/225 (60%)
		ARM	302..342	CDD:214547	28/39 (72%)
		armadillo repeat	306..342	CDD:293788	25/35 (71%)
		armadillo repeat	348..383	CDD:293788	24/34 (71%)
		armadillo repeat	391..439	CDD:293788	27/68 (40%)
		Arm	542..582	CDD:366143	29/39 (74%)
		armadillo repeat	555..581	CDD:293788	20/25 (80%)
		armadillo repeat	595..630	CDD:293788	26/34 (76%)
		armadillo repeat	636..674	CDD:293788	21/37 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H253
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250678at7742
OrthoFinder	1	1.000	-	-		FOG0008035
OrthoInspector	1	1.000	-	-		oto151909
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110