Protein Alignment PKP1 and pkp1

DIOPT Version :10

• Sequence 1: NP_000290.2
• Gene: PKP1 / 5317
• HGNCID: 9023
• Length: 747
• Species: Homo sapiens
• Sequence 2: XP_012809816.1
• Gene: pkp1 / 100496099
• XenbaseID: XB-GENE-949309
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 788
• Identity: 414/788 - (52%)
• Similarity: 534/788 - (67%)
• Gaps: 87/788 - (11%)

Human     4 SPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRG 68
            ||||||||.|.|...:.|:||:|||:.::.|.||.|||:|||||||||.||:||.||.   ..:.
 Frog     6 SPLKTALASEVFLWPNESSLAVPSDKCLRGGVSGDQRVKEQVMMTVKRHKSRSSTSSP---GYKS 67

Human    69 SMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRG 133
            |||:.:||..|....:.::.|||:|:.| |.||. |||||||  |.:|||||||.:||.:|....
 Frog    68 SMYETVADYNNMNYNNNANQYSKYQSAN-SIGYQ-YNGTLKR--DQQRFSSYSQADNWGQHRHMS 128

Human   134 SCNTTGAGSDICFMQKIKASRSEPDLY-CDPRGTLRKGTLGSKGQKTTQNRY------------- 184
            ..:....|||..:.|.:|:|||||||. .|.|.|||:           ||:|
 Frog   129 YASPLSPGSDFDYKQTLKSSRSEPDLTGPDVRATLRR-----------QNQYNQMQNQHHQQQRP 182

Human   185 ------SFYSTCSGQKAIKK----CPVRPPSCAS---------KQDPVYIPPISCN--------- 221
                  ||||..|.|:  ||    .|.|.||..|         :|...|......|
 Frog   183 GRAHNSSFYSYHSTQQ--KKRGPMTPARTPSSLSTVQQQQQQQQQQHCYYTNAQRNESNFQNFNI 245

Human   222 -KDLSFGHSRASSKICSED-IECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVY 284
             |..::|.....|::.:.| .:..|:|:.:||:.|...|:|:|..||.||||.|||||:||..||
 Frog   246 PKQDNYGTINVPSRMDTRDEFDAGGMTLDRAVELLGYPDDKFQMSGANYIQHACFQDENAKNLVY 310

Human   285 QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQ 349
            |..||.||::||:|||:|||||.|||||||||:::.|||||.::.|.|||||||:||.:.:||||
 Frog   311 QSNGISKLINLLQSPNENVQQATAGALRNLVFKNSANKLETSQKGGTREAVSLLKRTSHPDIQKQ 375

Human   350 LTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRL 414
            ||||||||||:|:||:||:.:|||||.:||:||:|||.:.:.:....::|||||||||||||
 Frog   376 LTGLLWNLSSSDQLKDELVKEALPVLNERVVIPYSGWSERSMSNQNCMLDPEVFFNATGCLR--- 437

Human   415 GMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479
                              ||||||.||:.|||..||:||||.|:|.|:|....||||||||.|:|
 Frog   438 ------------------NLSSADVGRKAMRNCPGLVDSLMFYIQKCLANKCPDDKSVENCACIL 484

Human   480 HNLSYRLDAEVPTRYRQL-EYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWL 543
            |||||.||:|||.:|.|| |...|....:|::||||||||:|:.|||:..|||||:.||||:..|
 Frog   485 HNLSYHLDSEVPNKYSQLDEQMYRLQQNDKTTTGCFSNKSEKLQNNNFQLPLPEEDANPKGAALL 549

Human   544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN 608
            .||.||||||:|:.:||||:|||||||||||||||||.||:||||:||||:||:|||.|||||||
 Frog   550 SHSSAIRTYLSLLEQSKKDSTLEACAGALQNLTASKGQMSNGMSQIIGLKDKGIPQITRLLQSGN 614

Human   609 SDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673
            :|||::|:||||||||||.||:.|..|..|:|:|:|:..:|.|.||||||||||||:|||..::|
 Frog   615 ADVVKAGSSLLSNMSRHPSLHKTMATQALPDVSRILSQSSGKTMNSEDILSSACYTMRNLAMAEP 679

Human   674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 738
            |:|||..|.::|.|::|:|:|.||||..||||:.|:|||:.:||||.|:|||.|::::|:|| :.
 Frog   680 QIAKQNISGNLLGNLVNMCKSGASPKVGEAARVFLTDMWAQRELQGFLKQQGLDKSIMGSLA-ST 743

Human   739 SLRNFTSR 746
            :|||...|
 Frog   744 ALRNTIPR 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKP1	NP_000290.2	Required for interaction with EIF4A1. /evidence=ECO:0000269|PubMed:20156963	1..286		132/325 (41%)
		Required for binding to single stranded DNA. /evidence=ECO:0000269|PubMed:20613778	1..234		107/272 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..68		10/19 (53%)
		Phosphorylation in this region is required for cytoplasmic localization and protein stabilization. /evidence=ECO:0000269|PubMed:23444369	54..69		5/14 (36%)
		Phosphorylation in this region is required for cytoplasmic localization and protein stabilization. /evidence=ECO:0000269|PubMed:23444369	116..191		34/94 (36%)
		Required for WNT-mediated nuclear localization. /evidence=ECO:0000250|UniProtKB:P97350	160..269		38/152 (25%)
		armadillo repeat	239..272	CDD:293788	14/33 (42%)
		ARM 2	275..316		29/40 (73%)
		ARM	276..316	CDD:214547	28/39 (72%)
		armadillo repeat	280..316	CDD:293788	25/35 (71%)
		ARM 3	317..359		27/41 (66%)
		armadillo repeat	322..357	CDD:293788	24/34 (71%)
		ARM 4	360..415		30/54 (56%)
		ARM 5	416..463		20/46 (43%)
		ARM 6	525..556		19/30 (63%)
		ARM 7	557..603		36/45 (80%)
		armadillo repeat	589..624	CDD:293788	26/34 (76%)
		ARM 8	604..649		27/44 (61%)
		armadillo repeat	630..668	CDD:293788	21/37 (57%)
		ARM 9	650..713		38/62 (61%)
		armadillo repeat	677..707	CDD:293788	16/29 (55%)
pkp1	XP_012809816.1	armadillo repeat	273..298	CDD:293788	11/24 (46%)
		Syo1_like	301..>506	CDD:474028	135/225 (60%)
		ARM	302..342	CDD:214547	28/39 (72%)
		armadillo repeat	306..342	CDD:293788	25/35 (71%)
		armadillo repeat	348..383	CDD:293788	24/34 (71%)
		armadillo repeat	391..439	CDD:293788	27/68 (40%)
		Arm	542..583	CDD:425727	30/40 (75%)
		armadillo repeat	555..581	CDD:293788	20/25 (80%)
		armadillo repeat	595..630	CDD:293788	26/34 (76%)
		armadillo repeat	636..674	CDD:293788	21/37 (57%)