DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKM and CG7069

DIOPT Version :10

Sequence 1:XP_047288618.1 Gene:PKM / 5315 HGNCID:9021 Length:609 Species:Homo sapiens
Sequence 2:NP_651030.1 Gene:CG7069 / 42621 FlyBaseID:FBgn0038952 Length:744 Species:Drosophila melanogaster


Alignment Length:462 Identity:221/462 - (47%)
Similarity:300/462 - (64%) Gaps:35/462 - (7%)


- Green bases have known domain annotations that are detailed below.


Human   147 MNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTG-LIKGSGTAEV 210
            |.|.|:|||||:||||.:||:..|.|...:.....|.|.:|:|||||||||||| |..|:..||:
  Fly     1 MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEI 65

Human   211 ELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEV 275
            |||.|..:.::......:|.:::.:::||:.:.::|:.|::::||||||:|.||:...|.::.:|
  Fly    66 ELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVICQV 130

Human   276 ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG 340
            ||||.|||.||:||||..||||:|:|||.||||||.||.|||:||||||.|:.:.|:|:|||..|
  Fly   131 ENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPAG 195

Human   341 KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICA 405
            ..||||||||||:|:...|:|:..||||||||||:|||||.|.|.||||.::.:||:.|||||||
  Fly   196 ACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVICA 260

Human   406 TQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHL 470
            |||:|||..||||||||.||||||:.||.|.:|||||||||.||:|.|:....|..:.||.:::.
  Fly   261 TQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWYE 325

Human   471 QLFEELRR---------LAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRA 526
            .|...|:|         ::.:|:...||..||...        ||:|.:.....|..|:..||..
  Fly   326 SLQNSLKREIRTSAADHISAVTTAIAEAATVGQAR--------AIVVASPCSMVAQMVSHMRPPC 382

Human   527 PIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNF--AMNVG-KARGFF------K 582
            ||:.:|.|...|.|:.|:|||:|:|.::.|..::        ||  .|..| |..|..      :
  Fly   383 PIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSF--------NFRRIMQSGLKLMGKMDILEPGQ 439

Human   583 KGDVVIV 589
            ||.||:|
  Fly   440 KGSVVLV 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKMXP_047288618.1 Pyruvate_Kinase 120..608 CDD:238178 221/462 (48%)
CG7069NP_651030.1 Pyruvate_Kinase 1..410 CDD:453956 209/416 (50%)
PTZ00121 <462..>741 CDD:173412
Blue background indicates that the domain is not in the aligned region.

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