Protein Alignment PKM and PyK

DIOPT Version :10

• Sequence 1: XP_047288618.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_524448.3
• Gene: PyK / 42620
• FlyBaseID: FBgn0267385
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 341/532 - (64%)
• Similarity: 414/532 - (77%)
• Gaps: 9/532 - (1%)

Human    77 AAMSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKE 141
            |...||:        :..|..||.|||.|||||||..|||....|.:||:|||||||.|||.|::
  Fly    10 APQLKPN--------EVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEK 66

Human   142 MIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSG 206
            |:.:|||:||:|||||:|||||.|:.|||.|.:::::......|||:||||||||||||||.|||
  Fly    67 MMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSG 131

Human   207 TAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFL 271
            |||:|||||..:|:|.:..::||....|:::||:||..||:.|::::||||||||.|::.|.|.|
  Fly   132 TAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSL 196

Human   272 VTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVL 336
            ..||||||||||:|||||||..||||||||||..||.|||||:|||:||||||.|:.:.|:||||
  Fly   197 TCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVL 261

Human   337 GEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKP 401
            |||||||||||||||.:|:...|||:||.||||||||||||||||||||||||.||.|||:||||
  Fly   262 GEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKP 326

Human   402 VICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAA 466
            |||||||||||:|||||||||.|||||||||||||:|||||||||:||||.|.......:|||||
  Fly   327 VICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAA 391

Human   467 IYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAV 531
            ::|..||.:|.|.|. |.|.:.|.|:.||||:.|..:.||:|:|.||:||.||::||||.|||||
  Fly   392 LWHQNLFNDLVRGAG-TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAV 455

Human   532 TRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG 596
            ||..|||||||||||:.|::.|:|....|.:|||:||.|.:.|||..||.|.||.|:|:|||:.|
  Fly   456 TRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQG 520

Human   597 SGFTNTMRVVPV 608
            ||||||:|:|.|
  Fly   521 SGFTNTIRIVTV 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKM	XP_047288618.1	Pyruvate_Kinase	120..608	CDD:238178	321/487 (66%)
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	321/486 (66%)