DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKM and CG7362

DIOPT Version :10

Sequence 1:XP_047288618.1 Gene:PKM / 5315 HGNCID:9021 Length:609 Species:Homo sapiens
Sequence 2:NP_650388.2 Gene:CG7362 / 41787 FlyBaseID:FBgn0038258 Length:793 Species:Drosophila melanogaster


Alignment Length:455 Identity:167/455 - (36%)
Similarity:233/455 - (51%) Gaps:93/455 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   105 LEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNV 169
            |::..||...:|.:....|.|||||||:|...|.|..:|.:||.|.||:||.|||:.|.:.|:..
  Fly    17 LDYQSRLQFQAPALRLPLTSIICTIGPSSSQPEVLLNLIHAGMKVVRLDFSDGTHDCHCQAIQAA 81

Human   170 RTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENI 234
            |.|...:|.:..|.|.:|:|||||||.|                                     
  Fly    82 RKAIAMYAEETGLPRSLAIALDTKGPVI------------------------------------- 109

Human   235 LWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAV 299
                                                                 |..|.|.||.|:
  Fly   110 -----------------------------------------------------NPQGVAADLNAI 121

Human   300 SEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLG--EKGKNIKIISKIENHEGVRRFDEIL 362
            :|:|..|||||.:|.|||:||||||.|..:.|:|:.||  ...::||||||||:.:.:...|||:
  Fly   122 TEQDKLDLKFGADQKVDMIFASFIRDAKALKEIRQALGACPSSEHIKIISKIESQQALANIDEII 186

Human   363 EASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVA 427
            ..|||||||.|::|.||..|.|.||||.::.:||:.|||||||.||:.|||.||||||||.||||
  Fly   187 RESDGIMVALGNMGNEIALEAVPLAQKSIVAKCNKVGKPVICANQMMNSMITKPRPTRAESSDVA 251

Human   428 NAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPI-TSDPTEATA 491
            ||:|||.|.::||.|||||.||::.|:....|..:.|:.:::..:...|:....| .:|...|.:
  Fly   252 NAILDGCDALVLSDETAKGKYPVQCVQCMARICAKVESVLWYESIQNNLKSEVRINAADHISAVS 316

Human   492 VGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPV 556
            ....||:....:.||:|.:.....:..|::.||..||:.:|..|..|.|:.|:||::|:|.|:.|
  Fly   317 TAIAEAATVSQAQAIVVASPCSIVSQMVSQMRPPCPIVLLTGCPHEAAQSLLFRGVYPLLVKEMV 381

Human   557  556
              Fly   382  381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKMXP_047288618.1 Pyruvate_Kinase 120..608 CDD:238178 163/440 (37%)
CG7362NP_650388.2 Pyruvate_Kinase 35..407 CDD:453956 163/437 (37%)
PTZ00121 <476..>791 CDD:173412
Blue background indicates that the domain is not in the aligned region.

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