DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKM and CG11249

DIOPT Version :10

Sequence 1:XP_047288618.1 Gene:PKM / 5315 HGNCID:9021 Length:609 Species:Homo sapiens
Sequence 2:NP_649346.1 Gene:CG11249 / 40409 FlyBaseID:FBgn0037115 Length:642 Species:Drosophila melanogaster


Alignment Length:493 Identity:99/493 - (20%)
Similarity:202/493 - (40%) Gaps:72/493 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   139 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTK-GPEIR-TG- 200
            :|..:..|:....:|...||...:...|..:|.|..|.:.:  |..||..::..| .|..: || 
  Fly   151 IKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLREAEISVSKE--LGFPVTSSVMVKISPRHQFTGG 213

Human   201 ---LIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYV---DDGLI 259
               ..:..|...|||.:|..:.:|:|..|.::.:.::::::.:.:  :|:|....::   :|  |
  Fly   214 FSTQFRQEGKKCVELVQGQKVILTVDRQYSDRSNADVIYVNARFL--IVDVHPLDFILIGED--I 274

Human   260 SLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFI- 323
            .|.|:...||.|...|..||.|.:...|..| |......:|.::::||.|..|..:::|.:..: 
  Fly   275 QLMVRSIHADHLKGCVARGGMLYAHMPVLFP-ARCRRFRISYEELEDLTFAREVGLNVVVSHIVG 338

Human   324 --RKASDVHEVRKVLGEKGKNI---KIISKIENHEG-----VRRFDEIL-EASDGIMVARGDLGI 377
              :...::......:...|..:   .::::::..:|     ::|:|..| |.::...|.  |:..
  Fly   339 TPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAEPATVP--DIMH 401

Human   378 EIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE 442
            ..|..:.|:....      .|.||:|...::|:....:..|.....:..                
  Fly   402 LCPDAECFMQLTY------AAKKPIIFDPRLLDEQKLRVDPAHYYYTFY---------------- 444

Human   443 TAKGDYPLEAVRMQHLIAREAEAAIYH--LQ--LFEELRRLAPITSDPTEATAVGA-------VE 496
                 ||.:.|    ....:.:..||.  ||  :||::...|...:...:.:..||       |.
  Fly   445 -----YPDKYV----TTCPQPKGTIYFRLLQSAIFEQISPTALANTPYCDRSHTGADSLARSVVT 500

Human   497 ASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWA 561
            ||.:..:.||:|:..:.|...:::.:||.|||:.|:..........:|..:..:..:.....|..
  Fly   501 ASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTKCIIAHR 565

Human   562 EDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGF 599
            .:|.|:..:|:.....|...|:.|.||::..:..|:.|
  Fly   566 RNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGTKF 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKMXP_047288618.1 Pyruvate_Kinase 120..608 CDD:238178 99/493 (20%)
CG11249NP_649346.1 Pyruvate_Kinase 158..>332 CDD:453956 44/180 (24%)
PK_C 492..594 CDD:460738 23/101 (23%)

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