Protein Alignment PKM and CG12229

DIOPT Version :10

• Sequence 1: XP_047288618.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Alignment Length: 477
• Identity: 106/477 - (22%)
• Similarity: 190/477 - (39%)
• Gaps: 72/477 - (15%)

Human   151 RLNFSHGTHEYHAETIKN-----------VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKG 204
            |....:||:.:|.:|:.|           :..|..:.:::..|.....:||:..|...|.|.::.
  Fly    91 RRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLRN 155

Human   205 SGTAEVELKKGATLKITLDNAYMEKCDENILW-LDYKNICKVVEVGSKIYVDDGLISLQVKQKGA 268
            :.|  |.|.:|..:.:|.|.:|..|..:.|:: ::.:.....|::|     |..:|..:|:.|..
  Fly   156 NCT--VMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLG-----DIVMIGREVRGKVV 213

Human   269 ----DFLVTEVENGGSLGSKKGVNLPGA--AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAS 327
                :.|...:.:.|.:.|...:.||..  |:|.....:..::||:.....:.:.|....||..|
  Fly   214 KTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKS 278

Human   328 DVHEVRKVLGEKGKNIKIISKIENHEGVR--RFD--EILEASDGIMVARGDL-GIEIPAEKVFLA 387
            .:..||:.| ....|:|:|..|: .|.||  ..|  .|::..|.|.:.  |: .:........:.
  Fly   279 FLRAVRQTL-NSDFNLKLIGMID-FEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIME 339

Human   388 QKMMIGRCNRAGKPVICATQMLE--SMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPL 450
            ..:.|.:|.:  |||| .|..||  |..|     |.|..|    .|...|.|.:........|||
  Fly   340 DVLPISQCQK--KPVI-GTVPLERCSDFK-----RFELHD----FLWKVDAIHIQKSPWCNKYPL 392

Human   451 EAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRS 515
             .|:....|......|:.:..:.:.:     :||..|....:....:|.:|  .||.:.|....:
  Fly   393 -IVKKLMPIKDYRVGAVQNKMVLKSI-----LTSYQTIVNFIIRTISSIEC--QAIFLFTTCETA 449

Human   516 AHQVARYRPRAPII------------AVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRV 568
            :..::|.....|:.            .:|...:.||..||.|.:.|||....:.|.....::..|
  Fly   450 SVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLYTKDLNECSYSPIEFGV 514

Human   569 NFAMNVGKARGFFKKGDVVIVL 590
            :|.    :.:|..:.||.|:.|
  Fly   515 DFM----RKKGCLEVGDFVVTL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKM	XP_047288618.1	Pyruvate_Kinase	120..608	CDD:238178	106/477 (22%)
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	97/438 (22%)