Protein Alignment PKM and CG2964

DIOPT Version :10

• Sequence 1: XP_047288618.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_608713.2
• Gene: CG2964 / 33475
• FlyBaseID: FBgn0031462
• Length: 554
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 220/504 - (43%)
• Similarity: 326/504 - (64%)
• Gaps: 4/504 - (0%)

Human   103 TFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIK 167
            |.|.|:|.||:.......|...:|.||..:||:.:|:..||..|:|:.||||||.:||.|::||:
  Fly    14 TQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKTIE 78

Human   168 NVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDE 232
            .:..|.|....:....|.||:|.||:||:|||||:.|    :|.|:.|..|:::::....:|.::
  Fly    79 LINEALERIHKETGQIRTVAIAADTRGPQIRTGLLDG----DVFLRSGDNLRLSINRDLYDKGNK 139

Human   233 NILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLP 297
            ..:::||.||..:.:.|.::::|||.:.|.:.:.|.|.|:.||.:||.|.:...|.||...:|||
  Fly   140 EAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLLCEVIHGGQLNNNCNVILPEIEIDLP 204

Human   298 AVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEIL 362
            ||||||:.|::|.::.:||.:|||.:|.|.:|.|:|.|||||||:||||:|:::...:.||.|||
  Fly   205 AVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSEIL 269

Human   363 EASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVA 427
            .|:||::::|.|||.:||.||:|:.||.::|:||:.|||||.|:.:||||...|.|||||..|:|
  Fly   270 RAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAECFDLA 334

Human   428 NAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV 492
            ||::|||||||||.|.|.|.:|.|.|.....:.||||..::...||.:|........|...:.|:
  Fly   335 NAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAHSLAI 399

Human   493 GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQ 557
            .|||.:.:..:..|||||.|||||..|:::|||.||:|:||..:|||..:|:||:.|:|......
  Fly   400 AAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYTLEPS 464

Human   558 EAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 606
            ..:|.|||.||.|||...|..|....||.:::::.|:.|.||||.:|||
  Fly   465 TDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRVV 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKM	XP_047288618.1	Pyruvate_Kinase	120..608	CDD:238178	214/487 (44%)
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:453956	214/486 (44%)