Protein Alignment PKLR and CG11249

DIOPT Version :10

• Sequence 1: NP_000289.1
• Gene: PKLR / 5313
• HGNCID: 9020
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_649346.1
• Gene: CG11249 / 40409
• FlyBaseID: FBgn0037115
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 493
• Identity: 109/493 - (22%)
• Similarity: 204/493 - (41%)
• Gaps: 72/493 - (14%)

Human   104 LKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTK-GPE------ 161
            :|..:..|:....:|...|:...:...|..:||| |......|.: ||..::..| .|.
  Fly   151 IKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLREA-EISVSKELGF-PVTSSVMVKISPRHQFTGG 213

Human   162 IRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYP-NIVRVVPVGGRIYIDDGLIS 225
            ..|...|.|.:. ||||:|.:|::|||..:..|.||:.::|:.. .||.|.|:...:..:|  |.
  Fly   214 FSTQFRQEGKKC-VELVQGQKVILTVDRQYSDRSNADVIYVNARFLIVDVHPLDFILIGED--IQ 275

Human   226 LVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFV-- 288
            |:|:.|..:.|...|..||:|.:...|..| |:.....:|.:::.||.|..|.|:::|.:..|
  Fly   276 LMVRSIHADHLKGCVARGGMLYAHMPVLFP-ARCRRFRISYEELEDLTFAREVGLNVVVSHIVGT 339

Human   289 -RKASDVAAVRAALGPEG---HGIKIISKIENHEG-----VKRFDEIL-EVSDGIMVARGDLGIE 343
             :...::....:|:..:|   :...::::::..:|     :||:|..| |:::...|.  |:...
  Fly   340 PKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAEPATVP--DIMHL 402

Human   344 IPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGET 408
            .|..:.|:....      .|.||::...::|:....:..|.....:..
  Fly   403 CPDAECFMQLTY------AAKKPIIFDPRLLDEQKLRVDPAHYYYTFY----------------- 444

Human   409 AKGNFPVEAVKMQHAIAREAEAAVYHRQL----FEELRRAAPLSRDP--------TEVTAIGAVE 461
                :|.:.|    ....:.:..:|.|.|    ||::...| |:..|        .:..|...|.
  Fly   445 ----YPDKYV----TTCPQPKGTIYFRLLQSAIFEQISPTA-LANTPYCDRSHTGADSLARSVVT 500

Human   462 AAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWA 526
            |:.:..|.||:|:..|.|..|.:|.:||.|.::.|:....|...|.:...|..|.:|........
  Fly   501 ASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTKCIIAHR 565

Human   527 DDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 564
            .:|..:..:.:.....|...:..|.||:|..:..|:.:
  Fly   566 RNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGTKF 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKLR	NP_000289.1	Pyruvate_Kinase	85..573	CDD:238178	109/493 (22%)
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:453956	52/179 (29%)
		PK_C	492..594	CDD:460738	25/101 (25%)