Protein Alignment PKLR and CG2964

DIOPT Version :10

• Sequence 1: NP_000289.1
• Gene: PKLR / 5313
• HGNCID: 9020
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_608713.2
• Gene: CG2964 / 33475
• FlyBaseID: FBgn0031462
• Length: 554
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 226/504 - (44%)
• Similarity: 326/504 - (64%)
• Gaps: 4/504 - (0%)

Human    68 TFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIA 132
            |.|.|:|.||:..:....|..|:||||..:||:.:.:..||..|:||.||||||.|||.|:::|.
  Fly    14 TQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKTIE 78

Human   133 NVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNA 197
            .:.||:|.........|.||||.||:||:||||:|.|    :|.|..|..:.::::.....:||.
  Fly    79 LINEALERIHKETGQIRTVAIAADTRGPQIRTGLLDG----DVFLRSGDNLRLSINRDLYDKGNK 139

Human   198 NTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLP 262
            ..|:||||||:.:...|.|::||||.:.|.:.::|.:||:.:|.:||.|.:...|.||..::|||
  Fly   140 EAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLLCEVIHGGQLNNNCNVILPEIEIDLP 204

Human   263 GLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEIL 327
            .:||:|:.|::|.::..||.:|||.||.|.:|..:|..||.:|..||||:|:::...:.||.|||
  Fly   205 AVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSEIL 269

Human   328 EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVA 392
            ..:||::::|.|||.:||.||:|:.||.::|:||..||||:.|:.:||||.|.|.|||||..|:|
  Fly   270 RAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAECFDLA 334

Human   393 NAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAI 457
            ||::|||||||||.|.|.|:||.|.|.....:.||||..::.|.||.:|........|.....||
  Fly   335 NAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAHSLAI 399

Human   458 GAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPE 522
            .|||.|.:..|..||||||:||||.|:|::|||..::|:||..:.||.|:|.|||.|:||...|.
  Fly   400 AAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYTLEPS 464

Human   523 AIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL 571
            ..:|.|||.||||.:.|.|..|.:..||.:::|:.|:.|.|:||.:||:
  Fly   465 TDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRVV 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKLR	NP_000289.1	Pyruvate_Kinase	85..573	CDD:238178	220/487 (45%)
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:453956	220/486 (45%)