DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD2 and Pkd2

DIOPT Version :9

Sequence 1:	NP_000288.1	Gene:	PKD2 / 5311	HGNCID:	9009	Length:	968	Species:	Homo sapiens
Sequence 2:	NP_001178863.1	Gene:	Pkd2 / 498328	RGDID:	1559992	Length:	966	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	876/969 - (90%)
Similarity:	911/969 - (94%)	Gaps:	6/969 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAAR 65
            ||||||||||.|||..|.|||||..||||:||    ||.||.||||.|||||||||:||||||||
  Rat     1 MVNSSRVQPQPPGDPGRSPAPRASGPGRLLAG----GAGLAVPGGLREQRGLEIEMERIRQAAAR 61

Human    66 DPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEE--EEEEVEGEEGGMVVEMDVEWRPGSRRSAAS 128
            ||||||:||||||||||||||||||||||||||  :::|||||||||||||||||||||||.|:|
  Rat    62 DPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVEGEEGGMVVEMDVEWRPGSRRPASS 126

Human   129 SAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERL 193
            |||||.|||.||||.|.||.:|||||||.||||.|||||.||||||||||||:||||||||||||
  Rat   127 SAVSSAGARGRGLGSYRGAAYPSGRRRRLEDQGAPCPSPAGGGDPLHRHLPLDGQPPRVAWAERL 191

Human   194 VRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFL 258
            ||||||||||||||||:.||||||:||||||||||.|||:||||||||||||||||||.:||||:
  Rat   192 VRGLRGLWGTRLMEESNANREKYLRSVLRELVTYLFFLILLCILTYGMMSSNVYYYTRTLSQLFI 256

Human   259 DTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQ 323
            ||||||||||||||||||||||||||||.|||||||.|.||.|:||||||||||||||||||:||
  Rat   257 DTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGLYWKAQSSNHTQADNRSFIFYENLLLGVPRLRQ 321

Human   324 LRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   322 LRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG 386

Human   389 AGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIP 453
            |||||||||||||||||:|.|::|.||||||||.|||||||||||||||||||||||||||||:|
  Rat   387 AGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLVEFPATGGVVP 451

Human   454 SWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLS 518
            ||||||:|||||||.||||||||||||||||.|||||||||||||:|:|||||||||||||||||
  Rat   452 SWQFQPVKLIRYVTAFDFFLAACEIIFCFFILYYVVEEILEIRIHRLNYFRSFWNCLDVVIVVLS 516

Human   519 VVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTM 583
            |||:.|||||.||.|.|||||||||:||||||:|||||||||||||.||.|||||||||||||||
  Rat   517 VVAMMINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNNIAAVMVFLVWIKLFKFINFNRTM 581

Human   584 SQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAE 648
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   582 SQLSTTMSRCAKDLFGFTIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAE 646

Human   649 IEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALV 713
            ||||||||||:|||||||||||||||||||||||:||||||||||||||||||||||||..||||
  Rat   647 IEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQKALV 711

Human   714 KLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQM 778
            |||||:||||.||||||||||||||||||||||||||||||||||||||||||||||||.|||||
  Rat   712 KLKLKRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQM 776

Human   779 RDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLV 843
            |||||:|||||||:||||||||||||||||||||||:||||||||||||||||||||||||||||
  Rat   777 RDDLEREREDLDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDSGHSSRRRGSISSGVSYEEFQVLV 841

Human   844 RRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERL 908
            |||||||||||||||||||||||||||||||:||||||||||||||||.||||||||||||||||
  Rat   842 RRVDRMEHSIGSIVSKIDAVIVKLEIMERAKVKRREVLGRLLDGVAEDARLGRDSEIHREQMERL 906

Human   909 VREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVH 967
            ||||||||||||||||..|||||.|||.||..||||||.||||.||:||.|||||:|.|
  Rat   907 VREELERWESDDAASQSGHGLGTQVGLGGQSHPRSSRPPSSQSAEGLEGGGGNGSTNAH 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		20/26 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..181		107/124 (86%)
		PKD_channel	269..687	CDD:400395	387/417 (93%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28092368	641..643		1/1 (100%)
		EFh_HEF	<724..792	CDD:355006	64/67 (96%)
		EF-hand motif	754..782	CDD:320075	26/27 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..831		62/66 (94%)
		Linker. /evidence=ECO:0000305\|PubMed:18694932	803..822		17/18 (94%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269\|PubMed:15692563	810..821		9/10 (90%)
		Fer4_24	834..868	CDD:407943	33/33 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	917..968		39/51 (76%)
Pkd2	NP_001178863.1	PKD_channel	265..685	CDD:285288	389/419 (93%)
Pkd2	NP_001178863.1	EFh	730..776	CDD:298682	44/45 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83684411
Domainoid	1	1.000	803	1.000	Domainoid score	I2646
eggNOG	1	0.900	-	-		E1_KOG3599
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20104
Inparanoid	1	1.050	1760	1.000	Inparanoid score	I1973
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50394
OrthoDB	1	1.010	-	-		D100623at7742
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		oto130418
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270