Protein Alignment PKD2 and pkd2

DIOPT Version :10

• Sequence 1: NP_000288.1
• Gene: PKD2 / 5311
• HGNCID: 9009
• Length: 968
• Species: Homo sapiens
• Sequence 2: XP_073792981.1
• Gene: pkd2 / 432387
• ZFINID: ZDB-GENE-040827-4
• Length: 928
• Species: Danio rerio
• Alignment Length: 963
• Identity: 610/963 - (63%)
• Similarity: 746/963 - (77%)
• Gaps: 72/963 - (7%)

Human     2 VNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARD 66
            ::||||:||         ||::|          |..||.:.|    ...|:|:|.....:.....
Zfish    25 MSSSRVRPQ---------APQSP----------AASASASPP----PHEGIEMEKMHHEEVGLGV 66

Human    67 PPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGS--RRSAASS 129
            |.    .:||.|.:|.|||||||||||||.||          ||   |:.:|.|.|  |||.:::
Zfish    67 PD----ETPSSPPTSSSRQAWSRDNPGFEPEE----------GM---MEADWPPESQGRRSVSTT 114

Human   130 AVSSVGARSRGL-GGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERL 193
            :.||.|    |: |.:.|.   |.|..|.....||...        ||           :..:|:
Zfish   115 SSSSSG----GVPGNFSGI---SARINRGLYPTPPAQE--------HR-----------SCGKRI 153

Human   194 VRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFL 258
            :..:|.||.|||:.||::|||.|||:||||::||:|||:.|||:||||:|:|:||||::||||||
Zfish   154 LEKMRVLWDTRLLGESNSNREMYLKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFL 218

Human   259 DTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQ 323
            |||:|..|.||||:||:||||||||||..|:|:||::..:|::..:|:|.|:||||||||||:||
Zfish   219 DTPLSSGEPTNFKSLSTMEDFWKFTEGPFLNGMYWELWYNNKSLPENQSLIYYENLLLGVPRLRQ 283

Human   324 LRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG 388
            |||||.|||:.:|||||:.:||:|||.::||:|||||:|||||.:..|..|..||:||.::||.|
Zfish   284 LRVRNESCSVHEDLRDEVYDCYNVYSPANEDKAPFGPKNGTAWRFKDESSLGESSYWGQVSTYGG 348

Human   389 AGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIP 453
            .|||.|||||||::|.|:..||.|:||||||||.|:|||:||.|:||||:||||||||||||.:|
Zfish   349 GGYYQDLSRTREKSANQLQELKNNLWLDRGTRAVFLDFSIYNGNVNLFCIVRLLVEFPATGGAVP 413

Human   454 SWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLS 518
            |||||.::|:|||:::|:|:..||:.||.|:.||:|||.||||:|:|.||:|.||||||:||.||
Zfish   414 SWQFQTVRLLRYVSSWDYFVGMCEVSFCLFVLYYLVEEALEIRLHRLRYFKSLWNCLDVLIVALS 478

Human   519 VVAIGINIYRTSNVEVLLQF-LEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRT 582
            |.||.:||.|||.|...|.| ||:.:|:||||.||..|:.|||:||:.||..|:|||||||||:|
Zfish   479 VPAIIMNICRTSAVSHRLHFLLENHSTYPNFEPLARLQVHFNNLAAIIVFLSWVKLFKFINFNKT 543

Human   583 MSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFA 647
            |:|||||||||||||.||||||||:||||||||||||||||:||||||.||||||||||||.:|:
Zfish   544 MNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVFGTQVNDFSTFQACIFTQFRIILGDFDFS 608

Human   648 EIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKAL 712
            |||||:.|||||||||||||:|.||||||||||||||||||:|:|||::|||::|||:|.|::|:
Zfish   609 EIEEADSVLGPIYFTTFVFFIFMILLNMFLAIINDTYSEVKADMAQQRSEMEITDLIKKSYNRAM 673

Human   713 VKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQ 777
            |||||||::::||.:||:|..|||:||||||||:||||:||||||||.|||.|||||||||||||
Zfish   674 VKLKLKKSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAKYDLDGDQELTEHEHQQ 738

Human   778 MRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVL 842
            ||||||||||||||:|||||||.|.|||.||.||||||||||||||||||||.|.||||||||||
Zfish   739 MRDDLEKEREDLDLEHSSLPRPASGRSFSRSQDDSEEDDDEDSGHSSRRRGSSSGGVSYEEFQVL 803

Human   843 VRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMER 907
            ||||||||||||||||||||||||||.|||||:|||:||||:||||.||||:|||.|:.||||:|
Zfish   804 VRRVDRMEHSIGSIVSKIDAVIVKLEAMERAKMKRRDVLGRILDGVMEDERMGRDPELQREQMDR 868

Human   908 LVREELERWESDDAASQIS--HGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGA 958
            |||:|||||||||..||:|  |...||:..:.|.|||||||.||.|.||.:.|
Zfish   869 LVRDELERWESDDTMSQVSHHHHQATPIISSAQLRPRSSRPPSSLSNEGPDAA 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		9/25 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..181		42/125 (34%)
		Polycystin_dom	269..463	CDD:466668	126/193 (65%)
		PKD_channel	464..687	CDD:462341	164/223 (74%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28092368	641..643		1/1 (100%)
		EFh_HEF	<724..792	CDD:355006	57/67 (85%)
		EF-hand motif	754..782	CDD:320075	25/27 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..831		60/66 (91%)
		Linker. /evidence=ECO:0000305|PubMed:18694932	803..822		16/18 (89%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269|PubMed:15692563	810..821		10/10 (100%)
		Fer4_24	834..868	CDD:436280	33/33 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	917..968		24/44 (55%)
pkd2	XP_073792981.1	None