DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD2 and pkd2

DIOPT Version :9

Sequence 1:	NP_000288.1	Gene:	PKD2 / 5311	HGNCID:	9009	Length:	968	Species:	Homo sapiens
Sequence 2:	NP_001002310.1	Gene:	pkd2 / 432387	ZFINID:	ZDB-GENE-040827-4	Length:	904	Species:	Danio rerio

Alignment Length:	963	Identity:	610/963 - (63%)
Similarity:	746/963 - (77%)	Gaps:	72/963 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     2 VNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARD 66
            ::||||:||         ||::|          |..||.:.|    ...|:|:|.....:.....
Zfish     1 MSSSRVRPQ---------APQSP----------AASASASPP----PHEGIEMEKMHHEEVGLGV 42

Human    67 PPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGS--RRSAASS 129
            |.    .:||.|.:|.|||||||||||||.||          ||   |:.:|.|.|  |||.:::
Zfish    43 PD----ETPSSPPTSSSRQAWSRDNPGFEPEE----------GM---MEADWPPESQGRRSVSTT 90

Human   130 AVSSVGARSRGL-GGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERL 193
            :.||.|    |: |.:.|.   |.|..|.....||...        ||           :..:|:
Zfish    91 SSSSSG----GVPGNFSGI---SARINRGLYPTPPAQE--------HR-----------SCGKRI 129

Human   194 VRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFL 258
            :..:|.||.|||:.||::|||.|||:||||::||:|||:.|||:||||:|:|:||||::||||||
Zfish   130 LEKMRVLWDTRLLGESNSNREMYLKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFL 194

Human   259 DTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQ 323
            |||:|..|.||||:||:||||||||||..|:|:||::..:|::..:|:|.|:||||||||||:||
Zfish   195 DTPLSSGEPTNFKSLSTMEDFWKFTEGPFLNGMYWELWYNNKSLPENQSLIYYENLLLGVPRLRQ 259

Human   324 LRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG 388
            |||||.|||:.:|||||:.:||:|||.::||:|||||:|||||.:..|..|..||:||.::||.|
Zfish   260 LRVRNESCSVHEDLRDEVYDCYNVYSPANEDKAPFGPKNGTAWRFKDESSLGESSYWGQVSTYGG 324

Human   389 AGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIP 453
            .|||.|||||||::|.|:..||.|:||||||||.|:|||:||.|:||||:||||||||||||.:|
Zfish   325 GGYYQDLSRTREKSANQLQELKNNLWLDRGTRAVFLDFSIYNGNVNLFCIVRLLVEFPATGGAVP 389

Human   454 SWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLS 518
            |||||.::|:|||:::|:|:..||:.||.|:.||:|||.||||:|:|.||:|.||||||:||.||
Zfish   390 SWQFQTVRLLRYVSSWDYFVGMCEVSFCLFVLYYLVEEALEIRLHRLRYFKSLWNCLDVLIVALS 454

Human   519 VVAIGINIYRTSNVEVLLQF-LEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRT 582
            |.||.:||.|||.|...|.| ||:.:|:||||.||..|:.|||:||:.||..|:|||||||||:|
Zfish   455 VPAIIMNICRTSAVSHRLHFLLENHSTYPNFEPLARLQVHFNNLAAIIVFLSWVKLFKFINFNKT 519

Human   583 MSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFA 647
            |:|||||||||||||.||||||||:||||||||||||||||:||||||.||||||||||||.:|:
Zfish   520 MNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVFGTQVNDFSTFQACIFTQFRIILGDFDFS 584

Human   648 EIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKAL 712
            |||||:.|||||||||||||:|.||||||||||||||||||:|:|||::|||::|||:|.|::|:
Zfish   585 EIEEADSVLGPIYFTTFVFFIFMILLNMFLAIINDTYSEVKADMAQQRSEMEITDLIKKSYNRAM 649

Human   713 VKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQ 777
            |||||||::::||.:||:|..|||:||||||||:||||:||||||||.|||.|||||||||||||
Zfish   650 VKLKLKKSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAKYDLDGDQELTEHEHQQ 714

Human   778 MRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVL 842
            ||||||||||||||:|||||||.|.|||.||.||||||||||||||||||||.|.||||||||||
Zfish   715 MRDDLEKEREDLDLEHSSLPRPASGRSFSRSQDDSEEDDDEDSGHSSRRRGSSSGGVSYEEFQVL 779

Human   843 VRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMER 907
            ||||||||||||||||||||||||||.|||||:|||:||||:||||.||||:|||.|:.||||:|
Zfish   780 VRRVDRMEHSIGSIVSKIDAVIVKLEAMERAKMKRRDVLGRILDGVMEDERMGRDPELQREQMDR 844

Human   908 LVREELERWESDDAASQIS--HGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGA 958
            |||:|||||||||..||:|  |...||:..:.|.|||||||.||.|.||.:.|
Zfish   845 LVRDELERWESDDTMSQVSHHHHQATPIISSAQLRPRSSRPPSSLSNEGPDAA 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..181		42/125 (34%)
		PKD_channel	269..687	CDD:400395	291/418 (70%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28092368	641..643		1/1 (100%)
		EFh_HEF	<724..792	CDD:355006	57/67 (85%)
		EF-hand motif	754..782	CDD:320075	25/27 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..831		60/66 (91%)
		Linker. /evidence=ECO:0000305\|PubMed:18694932	803..822		16/18 (89%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269\|PubMed:15692563	810..821		10/10 (100%)
		Fer4_24	834..868	CDD:407943	33/33 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	917..968		24/44 (55%)
pkd2	NP_001002310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		50/144 (35%)
		PKD_channel	204..624	CDD:285288	292/419 (70%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	578..580		1/1 (100%)
		EFh	<671..715	CDD:324233	38/43 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..770		55/61 (90%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	740..759		16/18 (89%)
		Pkinase	<781..>856	CDD:330832	63/74 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..904		24/44 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331023
Domainoid	1	1.000	631	1.000	Domainoid score	I1496
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20104
Inparanoid	1	1.050	1188	1.000	Inparanoid score	I1642
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50394
OrthoDB	1	1.010	-	-		D100623at7742
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		oto51331
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300