DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD2 and brv2

DIOPT Version :9

Sequence 1:	NP_000288.1	Gene:	PKD2 / 5311	HGNCID:	9009	Length:	968	Species:	Homo sapiens
Sequence 2:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	728	Identity:	169/728 - (23%)
Similarity:	280/728 - (38%)	Gaps:	143/728 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   157 REDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTN---REKYLK 218
            :||  ||..:..||  |...|:..            |...||.|....|:.|..||   .:|| |
  Fly    76 QED--PPYRAEEGG--PTMDHIGY------------LKIRLRSLRSELLISEGHTNEMLNQKY-K 123

Human   219 SVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFT 283
            .:..:|:.|..:.|.|.::.........||.|..|.:||.|........:....:..:..:.|.|
  Fly   124 HIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKIT 188

Human   284 EGSLLDGLY----------WKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLR 338
               |::..|          |.|:...:               :||.|:||:|        |.|..
  Fly   189 ---LVEAFYAQKTNGYEGWWAMEQWQK---------------IGVVRLRQMR--------PVDCH 227

Human   339 DEI-KECYDVYSVSSEDRAPFGPRNGTA--W-IYT-------SEKDLNG----SSHWGIIATY-S 387
            ..: |..:|..:.:.|.|.|:...:.|.  | ||.       ....|||    ..|:|.:..| .
  Fly   228 IGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPE 292

Human   388 GAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVI 452
            .|||.:.:..|:.....|:..|:...|||:.|.|.|||.::|||:.|||.::.|.||....|..:
  Fly   293 VAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQL 357

Human   453 PSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIR------IHKLHYFRSFWNCLD 511
            |......:.::..|.|    .:..|::   .:|.|.|..||..|      .|........|..:|
  Fly   358 PRVHVDSVSMLGNVET----RSNSELL---ILFVYTVLVILFARGVFTKIWHHPAAAHEAWTMVD 415

Human   512 VVIVVLSVVAIGINIYRTSNVEVLLQFLE--DQNTFPNFEH-LAYWQIQFNNIAAVTVFFVWIKL 573
            :.|.:|:|....:.|.|....:.|||.:|  .:..:.:|:. |...|:.| .:....|....::|
  Fly   416 LAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLF-IVKGFLVCITTLRL 479

Human   574 FKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFR 638
            :|.:.|.......:.|:....:.:....::..::.:|......:..|.....||...:.:.|...
  Fly   480 WKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMW 544

Human   639 IIL---GDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQK----- 695
            ..:   |||:.|:.....|:||.:.:...||.:..||:|:|.::|.|.::|....|.:..
  Fly   545 YSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSI 609

Human   696 -----AEMELSDL-------IRKGY----HKALVKLKLKKNTVDDISESLRQGGGKLNFDELR-- 742
                 ..:|.:||       :||.|    |.....::|:.|..:.|         |...|.::
  Fly   610 TFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELNRRELI---------KFKRDLIKSP 665

Human   743 QDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDL------DLDHSSLPRPMS 801
            |:||         .|:.|:..:..|..|...:..::...|..:.|.|      |.| ..||.|.:
  Fly   666 QELK---------RALLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKD-GKLPTPPA 720

Human   802 SRSFPRSLDDSEE 814
            |.|.|   ||..|
  Fly   721 SDSDP---DDMPE 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..181		8/23 (35%)
		PKD_channel	269..687	CDD:400395	104/455 (23%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28092368	641..643		0/4 (0%)
		EFh_HEF	<724..792	CDD:355006	14/75 (19%)
		EF-hand motif	754..782	CDD:320075	4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..831		16/57 (28%)
		Linker. /evidence=ECO:0000305\|PubMed:18694932	803..822		5/12 (42%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269\|PubMed:15692563	810..821		3/5 (60%)
		Fer4_24	834..868	CDD:407943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	917..968
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	104/460 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810