Protein Alignment PKD2 and Pkd2

DIOPT Version :10

• Sequence 1: NP_000288.1
• Gene: PKD2 / 5311
• HGNCID: 9009
• Length: 968
• Species: Homo sapiens
• Sequence 2: NP_032887.3
• Gene: Pkd2 / 18764
• MGIID: 1099818
• Length: 966
• Species: Mus musculus
• Alignment Length: 969
• Identity: 873/969 - (90%)
• Similarity: 908/969 - (93%)
• Gaps: 6/969 - (0%)

Human     1 MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAAR 65
            ||||.|||||.||||.|.|||||..||||:||    ||.||.||||.|||||||||:||||||||
Mouse     1 MVNSRRVQPQPPGDAGRSPAPRASGPGRLVAG----GAGLAVPGGLGEQRGLEIEMERIRQAAAR 61

Human    66 DPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEE--EEEEVEGEEGGMVVEMDVEWRPGSRRSAAS 128
            ||||||:||||||||||||||||||||||||||  :::|||||||||||||||||||||||||:|
Mouse    62 DPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVEGEEGGMVVEMDVEWRPGSRRSASS 126

Human   129 SAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERL 193
            |||||||||.||||.|.||.|.||||||.||||..||||.|||||||||||||||||||||||||
Mouse   127 SAVSSVGARGRGLGSYRGAAHLSGRRRRLEDQGAQCPSPAGGGDPLHRHLPLEGQPPRVAWAERL 191

Human   194 VRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFL 258
            ||||||||||||||||:.|||||||||||||||||.||:|||||||||||||||||||.:||||:
Mouse   192 VRGLRGLWGTRLMEESNANREKYLKSVLRELVTYLFFLVVLCILTYGMMSSNVYYYTRTLSQLFI 256

Human   259 DTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQ 323
            ||||||||||||||||||||||||||||.|||||||.|.||.|:||||||||||||||||||:||
Mouse   257 DTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGLYWKAQTSNHTQADNRSFIFYENLLLGVPRLRQ 321

Human   324 LRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG 388
            |||||||||||||||||||||||||||||||||||||||||||:|||||:|||||||||||:|||
Mouse   322 LRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWMYTSEKELNGSSHWGIIASYSG 386

Human   389 AGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIP 453
            |||||||||||||||||:|.|::|.||||||||.||||||||||||||||||||.||||||||:|
Mouse   387 AGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLAEFPATGGVVP 451

Human   454 SWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLS 518
            ||||||:|||||||.||||||||||||||||.|||||||||||||:|.|||||||||||||||||
Mouse   452 SWQFQPVKLIRYVTAFDFFLAACEIIFCFFIIYYVVEEILEIRIHRLSYFRSFWNCLDVVIVVLS 516

Human   519 VVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTM 583
            |||:.|||||.||.|.|||||||||:||||||:||||||||||:||.||.|||||||||||||||
Mouse   517 VVAMVINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNNISAVMVFLVWIKLFKFINFNRTM 581

Human   584 SQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAE 648
            |||||||||||||||||.|||.|||||||||||||||||||||||||||||||||||||||||||
Mouse   582 SQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAE 646

Human   649 IEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALV 713
            ||||||||||:|||||||||||||||||||||||:||||||||||||||||||||||||..||||
Mouse   647 IEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQKALV 711

Human   714 KLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQM 778
            |||||:||||.||||||||||||||||||||||||||||||||||||||||||||||||.|||||
Mouse   712 KLKLKRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQM 776

Human   779 RDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLV 843
            |||||||||||||:||||||||||||||||||||||:||||||||||||||||||||||||||||
Mouse   777 RDDLEKEREDLDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDSGHSSRRRGSISSGVSYEEFQVLV 841

Human   844 RRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERL 908
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Mouse   842 RRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDARLGRDSEIHREQMERL 906

Human   909 VREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVH 967
            ||||||||||||||||..||:.|.|||.|||.||:.||.||||.||:||.|||||:|||
Mouse   907 VREELERWESDDAASQTGHGVSTQVGLGGQPHPRNPRPPSSQSAEGLEGGGGNGSANVH 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		20/26 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..181		108/124 (87%)
		Polycystin_dom	269..463	CDD:466668	175/193 (91%)
		PKD_channel	464..687	CDD:462341	204/222 (92%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28092368	641..643		1/1 (100%)
		EFh_HEF	<724..792	CDD:355006	65/67 (97%)
		EF-hand motif	754..782	CDD:320075	26/27 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..831		63/66 (95%)
		Linker. /evidence=ECO:0000305|PubMed:18694932	803..822		17/18 (94%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269|PubMed:15692563	810..821		9/10 (90%)
		Fer4_24	834..868	CDD:436280	33/33 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	917..968		37/51 (73%)
Pkd2	NP_032887.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106		87/108 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..179		26/31 (84%)
		Polycystin_dom	267..461	CDD:466668	175/193 (91%)
		PKD_channel	462..685	CDD:462341	204/222 (92%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q13563	639..641		1/1 (100%)
		FRQ1	<732..772	CDD:444056	39/39 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..828		60/63 (95%)
		Linker. /evidence=ECO:0000250|UniProtKB:Q13563	801..820		17/18 (94%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000250|UniProtKB:Q13563	808..819		9/10 (90%)
		Fer4_24	832..866	CDD:436280	33/33 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..966		38/52 (73%)