DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD1 and Pkd1

DIOPT Version :9

Sequence 1:	XP_024306066.1	Gene:	PKD1 / 5310	HGNCID:	9008	Length:	4343	Species:	Homo sapiens
Sequence 2:	NP_001244281.1	Gene:	Pkd1 / 24650	RGDID:	3333	Length:	4292	Species:	Rattus norvegicus

Alignment Length:	4346	Identity:	3380/4346 - (77%)
Similarity:	3689/4346 - (84%)	Gaps:	57/4346 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRI 65
            |||.||||||||||||||||||||.||||||||..||.|.|||.||||||||||.|:||||:|||
  Rat     1 MPPGAPARLALALGLGLWLGALAGDPGRGCGPCPLPCFCSPAPDAACRVNCSGRWLQTLGPSLRI 65

Human    66 PADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECD 130
            ||||||||:|||||:.||:.||.|||.|.|||:|||:|||||||:|||||||||||||||||||:
  Rat    66 PADATALDLSHNLLQTLDIRLLVNLSGLVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECN 130

Human   131 CGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAV 195
            ||||||||||:||||.|||.||.||.||..|||:|||..||||:.|||||||||||||||.||||
  Rat   131 CGLAWLPRWAKEQQVHVVQSEATTCRGPVPLAGRPLLSTPLLDNACGEEYVACLPDNSSGAVAAV 195

Human   196 SFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCR 260
            .|..||:|.|:..||||||||.|:||||||||..|||||.|||:.|.||.|.||.........|.
  Rat   196 PFFFAHQGPLETAACSAFCFSAGEGLAALSEQNQCLCGAGQPSNTSAACSSWCSSILLSFNSACG 260

Human   261 GPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRY 325
            |||||||.|||||||.||||||||||||.|.|||.:|||:::|.|:|||||.|||.|||||:|.|
  Rat   261 GPTLLQHTFPASPGAALVGPHGPLASGQPADFHINSPLPISSTCWNFGDGSPEVDMAGPAATHSY 325

Human   326 VLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYS 390
            ||||.||||.||.||||||||.|:||||.||..|||||||.|.|||||||.|::||||.||..||
  Rat   326 VLPGGYHVTVVLTLGAGSALLETEVQVEVAPTVLELVCPSFVHSDESLDLGIRHRGGSALEVTYS 390

Human   391 IVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRF 455
            |:||.:|||:.||||||||||||||||||||||.|||.||||||||:.|||||||||||||:|.|
  Rat   391 ILALDKEPAQVVHPLCPSDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTWAGAALAMVDSPAIQHF 455

Human   456 LVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTD 520
            |||:||||||||||||:|:|.| |..|||||||||||||||||||||||.||||||||.|.||||
  Rat   456 LVSKVTRSLDVWIGFSSVEGKE-GLDPQGEAFSLESCQNWLPGEPHPATEEHCVRLGPAGQCNTD 519

Human   521 LCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSR 585
            ||||||||||||:|||||.||:|.|:|...|...|||.|||||..|..|.:||||||||||..|:
  Rat   520 LCSAPHSYVCELRPGGPVGDADNFLLGVSGGGRSGPLQPLAQQGTLQGPLQPVEVMVFPGLSPSQ 584

Human   586 EAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGA 650
            |||||.|||.||||..|.||||||||....|..||..||     .||.|:.||.|:|...|||||
  Rat   585 EAFLTAAEFETQELEDPVQLRLQVYRHSREAVAPEGSSE-----LDNSTEPAPKCVPEELWCPGA 644

Human   651 NICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLV 715
            |:|:|.||.|:...|.||..|..|||.|.|.||:||.||||||||.||.||||||||.|||||||
  Rat   645 NVCVPFDALCNSHVCINGSASRLGLPRASYTLWKEFFFSVPAGPPTQYLVTLHGQDVPMLPGDLV 709

Human   716 GLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTV 780
            .||||||||..|||..|...|| :|.|||.|||.|:.:||..||..||.|.|:|:||..|||||.
  Rat   710 ALQHDAGPGTFLHCPLASSCPG-QALYLSTNASDWMTNLPVHLEEAWAGPVCSLQLLLVTEQLTP 773

Human   781 LLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSAL 845
            ||||..||||:.||.|||||.|||.:||.||||||.|||||||||||:|.|.||.:|||||||.|
  Rat   774 LLGLGSNPGLQHPGHYEVRATVGNSISRQNLSCSFSVVSPVAGLRVIHPIPLDGHIYVPTNGSIL 838

Human   846 VLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVD 910
            ||||||||||||||.|.||:|||.||:.||..|......|..|.|.|||||:.||.|.||:|.|:
  Rat   839 VLQVDSGANATATAHWFGGNVSAPFEDACPPEVDFLKQDCTEEANGTLFSVLVLPRLKEGDHTVE 903

Human   911 VVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSL 975
            :|.:|.||:||||||||||||||||||.||||||||||:||||||:||||||:.|||||:|||||
  Rat   904 IVAQNGASQANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMVEAGSDVAFRWTIDDKQSL 968

Human   976 TFQNVVFNVIYQSAAVFKLSVGGRGWGGEGMGRGRAGAGSTFTSAFCSASCCPRTLPWLWLTASN 1040
            ||.|.|||||||:|||||||                                        |||||
  Rat   969 TFHNTVFNVIYQTAAVFKLS----------------------------------------LTASN 993

Human  1041 HVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALH 1105
            ||||:||||||||||||:|.||.||.|||||.||||||||.||||||||||||||.||||||.|.
  Rat   994 HVSNITVNYNVTVERMNKMHGLWVSAVPAVLPPNATLALTGGVLVDSAVEVAFLWNFGDGEQVLR 1058

Human  1106 QFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVA 1170
            ||:|||:|||.||||:|||||||||..|.|..||||.|||..||.:||||||||||||..||:|.
  Rat  1059 QFKPPYDESFQVPDPTVAQVLVEHNTTHIYNTPGEYNLTVTVSNTYENLTQQVPVSVRTVLPNVT 1123

Human  1171 VGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNN 1235
            :|:|..||:||:|:||:|:||||..|||||||||||||||.||||..||||:..|||.:.|||||
  Rat  1124 IGMSSNVLLAGQPITFFPYPLPSADGVLYTWDFGDGSPVLIQSQPVLNHTYSMTGTYRISLEVNN 1188

Human  1236 TVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATV 1300
            |||..||..|:.||:||.||:|.::.:||||||:||:|:|::|||||||||||||||.:||||||
  Rat  1189 TVSSVAAHVDICVFQELHGLTVYLNQSVEQGAPMVVNASVESGDNITWTFDMGDGTVFTGPEATV 1253

Human  1301 EHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYL 1365
            |||||||||.||||||.||||||::||||.||||||||:||:.||||||.|::.|:|||:|||||
  Rat  1254 EHVYLRAQNFTVTVGATSPAGHLSQSLHVQVFVLEVLRIEPSTCIPTQPSAQIMAHVTGDPAHYL 1318

Human  1366 FDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQ 1430
            |||||||||||.||.|.|:|||||||||.|||||||||.||:||||||||||||:.|||||||||
  Rat  1319 FDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVNKAHYFTSICVEPEICNVTLQPERQ 1383

Human  1431 FVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAAN 1495
            .|:|||||||||..|||||||||||||||::..|:..|.|||||||:||||||.||.|||||:.|
  Rat  1384 VVKLGDEAWLVAYPWPPFPYRYTWDFGTEDSIHTQTGGSEVTFIYREPGSYLVIVTVSNNISSTN 1448

Human  1496 DSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNST 1560
            |||.|:|||||.||.|::|||..|||||||||||:|.|.||:|||:||||...|||||||.|:||
  Rat  1449 DSAFVDVQEPVSVTGIRINGSHVLELQQPYLFSAMGNGSPAAYLWELGDGSQHEGPEVTHIYSST 1513

Human  1561 GDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLC 1625
            |||||||:||||||||||.||:|||:|||||.:|||||||||||||||||.||.||||.||||||
  Rat  1514 GDFTVRVSGWNEVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLC 1578

Human  1626 DRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVG--GGRYFPTNH 1688
            ||||||||||||||||||||||||||||||||||||||||:|||||||||||||  ||..||||:
  Rat  1579 DRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFIYVLQLIEGLQVVGGDGGCCFPTNY 1643

Human  1689 TVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMD 1753
            |:||||.||||||:||||||.:|.||.|..|||.||||.|:|.||:|.||||||||||.|:.|:|
  Rat  1644 TLQLQAAVRDGTNISYSWTAQQDGGPTLISSGKSFSLTALKASTYYVHLRATNMLGSASANRTID 1708

Human  1754 FVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHL 1818
            |||||..|:::|||||||||||:||.|||||||||||||.||||||.|||.|.|||:|..|||||
  Rat  1709 FVEPVESLILSASPNPAAVNTSLTLGAELAGGSGVVYTWYLEEGLSRETSMPSTTHTFAAPGLHL 1773

Human  1819 VTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPG 1883
            |.:||.|.|||.|||:||.||.||.|||||.|||...||||||:||||||||.||||:|||.:||
  Rat  1774 VRVTAENQLGSVNATIEVAVQAPVGGLSIRTSEPDSIFVAAGSTVPFWGQLAEGTNVTWCWTLPG 1838

Human  1884 GSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQ 1948
            | ||...::.:.||.||.||:.||||||||||||.||||.||||:.||||||||||||||.||||
  Rat  1839 G-SKYSQYIDVRFPAAGHFSLWLNASNAVSWVSAVYNLTVEEPIMNLVLWASSKVVAPGQPVHFQ 1902

Human  1949 ILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSG 2013
            |||||||||||||||||:.|||||...|||||.|||||:|||:.:||||.|||||||:||||:.|
  Rat  1903 ILLAAGSAVTFRLQVGGSIPEVLPSLHFSHSFFRVGDHMVSVQAENHVSRAQAQVRILVLEAIVG 1967

Human  2014 LQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEI 2078
            ||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat  1968 LQVPNCCEPGMATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGILEI 2032

Human  2079 QVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQ 2143
            .|||||.||..|.|||:||||.:|||.||||.|||||||:||||||||||||.||||||||:|.|
  Rat  2033 HVRAFNELGGVNLTLVVEVQDIIQYVTLQSGRCFTNRSARFEAATSPSPRRVTYHWDFGDGTPVQ 2097

Human  2144 DTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNY 2208
            :|:|...:|.||.||||||:|||:||||||||||||||||||||||||:|.||||||||||||||
  Rat  2098 ETEESWTDHYYLHPGDYRVEVNATNLVSFFVAQATVTVQVLACREPEVEVALPLQVLMRRSQRNY 2162

Human  2209 LEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFV 2273
            ||||||||:||:||||||||||||.|||||||..::.|||||||||:||:|||||||||||||||
  Rat  2163 LEAHVDLRNCVSYQTEYRWEVYRTTSCQRPGRMTQMVLPGVDVSRPQLVVPRLALPVGHYCFVFV 2227

Human  2274 VSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHW 2338
            ||||||||.:|||||||||.||||||||||||||||||:|||||||:||||||||||||||:|||
  Rat  2228 VSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLEDGDQTPLNFHW 2292

Human  2339 ACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRV 2403
            |||||||.|.|||.|||||||||.||||.|||.|||||||:|.||||||||||||||||||||||
  Rat  2293 ACVASTQSETGGCVLNFGPRGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTVLIRSGRV 2357

Human  2404 PIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAG 2468
            ||||||||||||||||||||||||||||.|.|||||||:|||||||||||||:|:|.||||||.|
  Rat  2358 PIVSLECVSCKAQAVYEVSRSSYVYLEGHCHNCSSGSKQGRWAARTFSNKTLMLNENTTSTGSTG 2422

Human  2469 MRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHF 2533
            |.||:|.|.|.|||||.|||||||.||||||||||||.|||||||||||||||.:|..|||||||
  Rat  2423 MHLVVRPGALHDGEGYIFTLTVLGHSGEEEGCASIRLLPNRPPLGGSCRLFPLESVRGLTTKVHF 2487

Human  2534 ECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQ 2598
            |||||.||||.||||||||.|:||.|.:||:||:||||||:|||||||||:|.|.|.|.|||:||
  Rat  2488 ECTGWRDAEDGGAPLVYALRLKRCHQNYCEDFCIYKGSLSTYGAVLPPGFQPLFVVSLTVVVEDQ 2552

Human  2599 LGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYE 2663
            |||:||||||||.|.||||:|:...|..|||.|||||||||||||||||||||||||:|||||||
  Rat  2553 LGASVVALNRSLTIVLPEPSGNPADLIPWLHSLTASVLPGLLRQADPQHVIEYSLALITVLNEYE 2617

Human  2664 RALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTL 2728
            :|.|:.:||..|:|.|||:||||||||:||||:||||||||.|||||||..||||:||||||:.|
  Rat  2618 QAPDMVSEPNLEQQLRAQMRKNITETLISLRVNTVDDIQQITAALAQCMVSSRELMCRSCLKKML 2682

Human  2729 HKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAY 2793
            .|||.||.|||||||.||:|||.|.|||||||||||||||.|::.|||.|||||.||.||||:||
  Rat  2683 QKLEGMMRILQAETTEGTLTPTTIADSILNITGDLIHLASLDMQGPQPLELGAEPPSLMVASKAY 2747

Human  2794 NLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALAN 2858
            ||:||||.||||||||||||||||||||||.|||:||.||||||.|.||.|||||||||||||::
  Rat  2748 NLSSALMCILMRSRVLNEEPLTLAGEEIVALGKRADPLSLLCYGKAWGPSCHFSIPEAFSGALSD 2812

Human  2859 LSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWA 2923
            ||||||||.|||||||||||||||||||||||||||||.|.|||||:||:|||||||||||||.|
  Rat  2813 LSDVVQLILLVDSNPFPFGYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQA 2877

Human  2924 ARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHS 2988
            |   :||.:...|.:|||:|||.||||.|:|||.|||||::.||:|:..|||||.||||||||||
  Rat  2878 A---QSSHSPVGSTIVQPRASVSAVVTADNSNPQAGLHLRITYTVLNARYLSEEREPYLAVYLHS 2939

Human  2989 EPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTS 3053
            ..:|||:||||||||..|.|:|||||||||||:||:.....||:|||:|||.||||:||||||||
  Rat  2940 VSQPNEYNCSASRRISLEVLEGADHRPYTFFIAPGTGTLGRSYYLNLTSHFHWSALEVSVGLYTS 3004

Human  3054 LCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVM 3118
            ||||||||.|:|||||::|||||||.|||||||||||||||||||||||:|:||||:..:||||:
  Rat  3005 LCQYFSEEAMMWRTEGIVPLEETSPSQAVCLTRHLTAFGASLFVPPSHVQFIFPEPSVSINYIVL 3069

Human  3119 LTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLY 3183
            |||.:|||||::||.||.||||||.||.|.|||||:.|||||||||||||.||||||||||||||
  Rat  3070 LTCVICLVTYVIMAMILRKLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHVGIMLY 3134

Human  3184 GVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTA 3248
            |.|:|||||||||||||||||||||:||||.|||||||||||||||||||||||||:||||||:|
  Rat  3135 GEDNRSGHRHLDGDRAFHRNSLDIFQIATPQSLGSVWKIRVWHDNKGLSPAWFLQHIIVRDLQSA 3199

Human  3249 RSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRS 3313
            ||.||||||||||||||||||||||||||::|||.:|:|||||||||||||||||||||||||||
  Rat  3200 RSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPPRS 3264

Human  3314 RFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYL 3378
            ||||:||.||||||:||||.|||||||.|||:.||.|.||.|...||||||:|||||||||||||
  Rat  3265 RFTRVQRVTCCVLLLCLFLAANAVWYGVVGDTTYSMGPVSSLMSPSVDTVAIGLVSSVVVYPVYL 3329

Human  3379 AILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLD 3443
            |:|||||||||||:|..:|||.|||.||:||.||.||||||.||.|||  .:||.||:|:||||:
  Rat  3330 AVLFLFRMSRSKVSGDQNPTPTGQQALDVDSYLDPSVLDSSLLTLSGL--TEAFSGQVKNDLFLE 3392

Human  3444 DSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSAS 3508
            |:||||||||.||||||||||||||::.|.|::||:|:.|..||.||||.||.||..|||..|||
  Rat  3393 DAKSLVCWPSSEGTLSWPDLLSDPSVMSSTLQRLAQGRPGCMLGSEEDGASLVSPSLPAKYLSAS 3457

Human  3509 DEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQA 3573
            |||||.||||:|.::|.||||..:|.|||:||||.||||||||.||.:||..|||.||.|||...
  Rat  3458 DEDLIHQVLADGANNPDPTQDALIERDLLTSLSSAPGEKTETLILQTMGEKRPPSMGLTWEQSPV 3522

Human  3574 ARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLA 3638
            .|||||||||||||||||.|||.|||||||||||||||||||:||||||.|||.||||||:||||
  Rat  3523 TRLSRTGLVEGLRKRLLPTWCAPLAHGLSLLLVAVAVAVSGWIGASFPPSVSVMWLLSSSSSFLA 3587

Human  3639 SFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARK 3703
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
  Rat  3588 SFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSERVPRVRPPHGFALFLAKEEARK 3652

Human  3704 VKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMA 3768
            |||||.||:|||||||||||||||:|||||||||||||||||||||.|:||||||||:|.||||:
  Rat  3653 VKRLHDMLKSLLVYMLFLLVTLLANYGDASCHGHAYRLQSAIKQELDSQAFLAITRSDEFWPWMS 3717

Human  3769 HVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWES-PHNGS 3832
            |||||||||||||||||||||||||||||..|||.... |.|||.|..|||||.:||:| ..|||
  Rat  3718 HVLLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSSSE-HMCSATGSLSTSDYGIGWQSVVQNGS 3781

Human  3833 GTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRY 3897
            .|||||||||||||.||.|||||||||:|||||||||||.||.|||||||||:|...:|:|||||
  Rat  3782 ETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRWVLMFVELTRY 3846

Human  3898 SPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTW 3962
            |||||||||||||||||.||.||||.|||||||||||.||||||||||||||||::|:|||..||
  Rat  3847 SPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVCLLLFALYFSVAEVHTW 3911

Human  3963 HREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAA 4027
            .|||..|..|..||||||||.|||||.||||||||.|||||||||...|..||||||||||.|.|
  Rat  3912 RREGCARTARPEAWARWLLVMLTAATGLVRLAQLGIADRQWTRFVHDHPHHFTSFDQVAQLGSVA 3976

Human  4028 RGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCV 4092
            |||||||||||||||||||||||||||||||||||||||:|.|||||:|||||||:||||:||..
  Rat  3977 RGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGA 4041

Human  4093 DSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGEL 4157
            |:|:|:|:|.||||||..:.||||:|||:|||||||||||||:|||||||||:||||||||||||
  Rat  4042 DTLYSMARAFLVLCPGARVPTLCPSESWYLSPLLCVGLWALRVWGALRLGAVLLRWRYHALRGEL 4106

Human  4158 YRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGS 4222
            |||||||||||||||||||||||||.|||||||||||||||:|||||||||||.||.||||||||
  Rat  4107 YRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRHKVRFEGMDPLPSRSSRGSKSSPVVPPPSAGS 4171

Human  4223 DASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQ 4287
            :||||||||||.||||..|||...|.|||||||.||||:||.|||||||||||||||||||.||:
  Rat  4172 EASHPSTSSSQPDGLSAGLGRSALRLEPEPSRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLR 4236

Human  4288 GRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST 4343
            |...|..|:..|.|..|..:|||||||||||:|.|..|||||..|...||||||||
  Rat  4237 GHGHSGPPSSPSPGGFPASQPALPSRLARASQGPDQTTGPSRVSLWPNNKVHPSST 4292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD1	XP_024306066.1	LRR	<50..>126	CDD:227223	61/75 (81%)
		leucine-rich repeat	70..92	CDD:275378	15/21 (71%)
		leucine-rich repeat	93..116	CDD:275378	18/22 (82%)
		PCC	97..2768	CDD:188093	2034/2672 (76%)
		leucine-rich repeat	117..129	CDD:275378	11/11 (100%)
		GPS	3051..3100	CDD:197639	43/48 (90%)
		PLAT_polycystin	3158..3277	CDD:238850	110/118 (93%)
		PKD_channel	3751..4153	CDD:332708	323/402 (80%)
Pkd1	NP_001244281.1	LRRNT	32..71	CDD:214470	30/38 (79%)
		LRR_8	61..127	CDD:290566	53/65 (82%)
		leucine-rich repeat	70..92	CDD:275378	15/21 (71%)
		LRR_4	72..108	CDD:289563	25/35 (71%)
		leucine-rich repeat	93..116	CDD:275378	18/22 (82%)
		PCC	97..2722	CDD:188093	2034/2672 (76%)
		leucine-rich repeat	117..129	CDD:275378	11/11 (100%)
		LRRCT	125..177	CDD:214507	38/51 (75%)
		WSC	177..271	CDD:214616	63/93 (68%)
		PKD	277..344	CDD:279180	50/66 (76%)
		CLECT	406..530	CDD:214480	108/124 (87%)
		PKD	927..1007	CDD:214510	69/119 (58%)
		PKD	1017..1115	CDD:214510	77/97 (79%)
		PKD	1124..1195	CDD:279180	48/70 (69%)
		PKD	1214..1278	CDD:279180	52/63 (83%)
		PKD	1289..1370	CDD:214510	64/80 (80%)
		PKD	1378..1449	CDD:279180	53/70 (76%)
		PKD	1471..1538	CDD:214510	52/66 (79%)
		PKD	1546..1615	CDD:279180	64/68 (94%)
		PKD	1635..1703	CDD:279180	49/67 (73%)
		PKD	1718..1787	CDD:279180	52/68 (76%)
		PKD	1807..1871	CDD:279180	43/64 (67%)
		PKD	1886..1955	CDD:279180	56/68 (82%)
		PKD	1974..2045	CDD:279180	63/70 (90%)
		PKD	2062..2129	CDD:279180	51/66 (77%)
		GPS	3002..3051	CDD:197639	43/48 (90%)
		PLAT_polycystin	3109..3228	CDD:238850	110/118 (93%)
		PKD_channel	3700..4102	CDD:285288	323/402 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696571
Domainoid	1	1.000	779	1.000	Domainoid score	I2831
eggNOG	1	0.900	-	-		E1_KOG3599
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H250
Inparanoid	1	1.050	6745	1.000	Inparanoid score	I47
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43679
OrthoDB	1	1.010	-	-		D1261at32523
OrthoFinder	1	1.000	-	-		FOG0010625
OrthoInspector	1	1.000	-	-		oto138074
orthoMCL	1	0.900	-	-		OOG6_110756
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X8124
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.170