Protein Alignment PITX3 and Drgx

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_001097075.2
• Gene: Drgx / 5740176
• FlyBaseID: FBgn0085369
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 472
• Identity: 110/472 - (23%)
• Similarity: 149/472 - (31%)
• Gaps: 218/472 - (46%)

Human    12 RSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQE 76
            |.|.|....|.| ||.                .|.|......::..:::||||.||.||.|||:|
  Fly    19 RLPTLDYPFAAT-HPY----------------TSYSYHPAIHDETFVRRKQRRNRTTFTLQQLEE 66

Human    77 LEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER--SQQAELCKGSFAAPLGG 139
            ||..|.:..|||:.|||::|:..|||||||:|||:||||||||.||  .:|.:...|..::.|..
  Fly    67 LETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDEQRKRENGESSSSLDK 131

Human   140 L--------------------VPPYEEVYP---------------GYSYGNWPPKALAPPLAAKT 169
            |                    :||.:..:.               .:|:...|...:....:...
  Fly   132 LHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHSRSPGGGMHLDSSDNE 196

Human   170 FPFAFNSVNVGP------LASQPVFSP---------------------PSS-------------- 193
            .|.:.|.:...|      |.|....||                     |||
  Fly   197 RPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGGGQGPSSPSNSRNTDSPIEVG 261

Human   194 ----------IAAS-----------------MVPSAAAAPGTVPGPGALQGLGGGPP------GL 225
                      :|||                 .:|.::||.....|.......|||..      |.
  Fly   262 GPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAAAAFGSHIFGNFGGGSNASDSNCGF 326

Human   226 APAAVSSGAVSCPYASAAAAAAA------------------------------------------ 248
            .|......||    |:|||||||
  Fly   327 RPVLSEQSAV----AAAAAAAAAQRSANHPPLFLPPHLAAQFTHQPLFPGLKGVSPFQSLCSCCS 387

Human   249 -----------------------AASSPY--------VYRDPCNSSLASLRLKAKQH-------- 274
                                   |||||.        ...||.::|:|.||.||::|
  Fly   388 LKPPPPPGSSVVAPLSIPVSSSSAASSPESPKSSGQGSVHDPRSNSVAELRRKAQEHSAALLQSL 452

Human   275 -----ASFSYPAVHGPP 286
                 |..::|.:|.||
  Fly   453 HAAAAAGLAFPGLHLPP 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		16/58 (28%)
		Homeodomain	63..119	CDD:459649	36/55 (65%)
		OAR	258..275	CDD:461067	9/29 (31%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		7/25 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		2/3 (67%)
Drgx	NP_001097075.2	Homeodomain	53..109	CDD:459649	36/55 (65%)
		OAR	428..446	CDD:461067	9/17 (53%)