Protein Alignment PITX3 and hbn

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 284
• Identity: 89/284 - (31%)
• Similarity: 127/284 - (44%)
• Gaps: 86/284 - (30%)

Human    35 GQEHSDSEKASASLPGGSP-EDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVW 98
            |.:..:.::.|:||..|.. .|....:|.||.||.||:.||.:||..|::.:|||:.|||::|:.
  Fly   125 GLDVDNDDELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMR 189

Human    99 TNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGL--------VPPYEEVYPGYSYGN 155
            .:|:||||:|||:||||||||||:....:  |..:..|..||        :||:.  .||:. |:
  Fly   190 LDLSEARVQVWFQNRRAKWRKREKFMNQD--KAGYLLPEQGLPEFPLGIPLPPHG--LPGHP-GS 249

Human   156 -----WPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAP--------- 206
                 |||.            ||.:.          .|:|.::.||.::|....||
  Fly   250 MQSEFWPPH------------FALHQ----------HFNPAAAAAAGLLPQHLMAPHYKLPNFHT 292

Human   207 --GTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRL 269
              ....|...|.|:                    :.:.|||||||||:.|    |.|.||
  Fly   293 LLSQYMGLSNLNGI--------------------FGAGAAAAAAAASAGY----PQNLSL----- 328

Human   270 KAKQHASFSYPAVHGPPPAANLSP 293
                ||..|..: ...||.:|.||
  Fly   329 ----HAGLSAMS-QVSPPCSNSSP 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		12/36 (33%)
		Homeodomain	63..119	CDD:459649	32/55 (58%)
		OAR	258..275	CDD:461067	4/16 (25%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		2/12 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	32/55 (58%)