Protein Alignment PITX3 and E5

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 142
• Identity: 41/142 - (28%)
• Similarity: 62/142 - (43%)
• Gaps: 29/142 - (20%)

Human    22 GTPHP-QLPEHGCKGQEHSDSEKASASLPGGSP-------EDGSL------------KKKQRRQR 66
            |.||| ..|.||     |.....|...:....|       ..|.:            .:|.:|.|
  Fly   248 GGPHPGHPPPHG-----HHPFGSAPHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVR 307

Human    67 THFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER----SQQAE 127
            |.|:..||.:||..|:.|.|...:.|:::|...:|||.:|:|||:|||.|.::.::    ....:
  Fly   308 TAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTK 372

Human   128 LCKGSFAAPLGG 139
            ..|||.:...||
  Fly   373 SNKGSSSGGGGG 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		16/68 (24%)
		Homeodomain	63..119	CDD:459649	24/55 (44%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	24/55 (44%)