DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PITX3 and Ptx1

DIOPT Version :9

Sequence 1:	NP_005020.1	Gene:	PITX3 / 5309	HGNCID:	9006	Length:	302	Species:	Homo sapiens
Sequence 2:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	278	Identity:	120/278 - (43%)
Similarity:	154/278 - (55%)	Gaps:	60/278 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    50 GGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRR 114
            |..|::....|:|||||||||||||||||.||.||||||||||||||:|||||||||||||||||
  Fly   252 GEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRR 316

Human   115 AKWRKRER-SQQAELCKGSFAAPLG-GLVPPY--EEVYPGYSYGNWPPKALAPPLAAKTFPFAFN 175
            |||||||| :..|.:....|.:..| ..:.|:  :.:|..|.|.||  ..:..||..|.||:..|
  Fly   317 AKWRKRERNAMNAAVAAADFKSGFGTQFMQPFADDSLYSSYPYNNW--TKVPSPLGTKPFPWPVN 379

Human   176 SVNVGPLASQPV----------FSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAV 230
                 ||.|...          |:..:|..|..:.:|:..||::              |.:.:..
  Fly   380 -----PLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSM--------------GSSLSNT 425

Human   231 SS-GAVS--CPYASAAAAAAAAASSPYVYR---DPC-----NSSLASLRLKAKQHASFSYPAVHG 284
            |: |||.  |||.:.|        :||:||   :||     :||:|:||||||||||..:.:.:.
  Fly   426 SNVGAVGAPCPYTTPA--------NPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYS 482

Human   285 PPP------AANLSPCQY 296
            .|.      :|.||.|||
  Fly   483 APSPVSRSNSAGLSACQY 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		11/20 (55%)
		Homeobox	66..119	CDD:395001	49/52 (94%)
		OAR	258..275	CDD:397759	12/21 (57%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	262..275		10/12 (83%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		3/3 (100%)
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	48/51 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3670
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm40595
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45882
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.070