Protein Alignment PITX3 and gsb

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Alignment Length: 270
• Identity: 86/270 - (31%)
• Similarity: 114/270 - (42%)
• Gaps: 47/270 - (17%)

Human    32 GCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIA 96
            |..|.|....:.|..|:        .||:||||.||.|::.|:..||..|.|.:|||:.||||:|
  Fly   163 GSVGSEDESEDDAEPSV--------QLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELA 219

Human    97 VWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSF--------AAPLGGLVPPYEEVYPGYSY 153
            ..|.||||||:|||.||||:.||:..:||..    ||        |.|.....|........||.
  Fly   220 QSTGLTEARVQVWFSNRRARLRKQLNTQQVP----SFAPTSTSFGATPTTSAAPAPNMGMSLYSS 280

Human   154 GNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGL 218
            .:||........||    :..:..::.|.:|.   |..||.|.|.|.:.|..|||  |...:...
  Fly   281 QSWPSSGAYENHAA----YGGSVASMSPASST---SGTSSAAHSPVQTQAQQPGT--GSEFMTST 336

Human   219 GGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHA----SFSY 279
            .|  .|.:.|...|.|.|.|...|.:|            :...|..||.......|.    |:::
  Fly   337 YG--VGSSNATYPSAAYSMPQTPATSA------------EQLRSQFASAAASGSHHPSTWDSYNF 387

Human   280 PAVHGPPPAA 289
            .....||.:|
  Fly   388 AGSFFPPASA 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		14/38 (37%)
		Homeodomain	63..119	CDD:459649	32/55 (58%)
		OAR	258..275	CDD:461067	3/16 (19%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		3/12 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
gsb	NP_523863.1	PAX	19..143	CDD:128645
		Homeodomain	186..242	CDD:459649	32/55 (58%)