Protein Alignment PITX3 and gsb-n

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_523862.1
• Gene: gsb-n / 38004
• FlyBaseID: FBgn0001147
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 97/374 - (25%)
• Similarity: 129/374 - (34%)
• Gaps: 142/374 - (37%)

Human     5 LLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGS---------LKK 60
            |:.|..|..|:.|...      :|.....:|.|....:.....:.||...|.|         ||:
  Fly   122 LIKEGFADPPSTSSIS------RLLRGSDRGSEDGRKDYTINGILGGRDSDISDTESEPGIPLKR 180

Human    61 KQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQ 125
            ||||.||.||::||:.||..|.|.:|||:.||||:|..|.|||||::|||.||||:.||......
  Fly   181 KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSN 245

Human   126 AELC---KGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPV 187
            :.|.   .||....:|                        ..|:..|.|..:..:.||.:|.
  Fly   246 SGLSPMNSGSSNVGVG------------------------VGLSGATAPLGYGPLGVGSMAG--- 283

Human   188 FSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAA--- 249
            :||              ||||. ..||  |:..|....|.|..|       :.|||.|||||
  Fly   284 YSP--------------APGTT-ATGA--GMNDGVHHAAHAPSS-------HHSAATAAAAAHHH 324

Human   250 ---------------------------ASSPYVYRD----------------------------- 258
                                       .|..|.::|
  Fly   325 TQMGGYDLVQSAAQHGFPGGFAQPGHFGSQNYYHQDYSKLTIDDFSKLTADSVSKISPSLHLSDN 389

Human   259 ------PCNSSLASLRLKAKQHA--------SFSYPAVHGPPPAANLSP 293
                  |.|.|.|:....|..:|        .::..|.||.|.:|...|
  Fly   390 YSKLEAPSNWSQAAYHAAANYNAHVAQHQLNDYAAAAAHGNPASAYSHP 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		21/74 (28%)
		Homeodomain	63..119	CDD:459649	33/55 (60%)
		OAR	258..275	CDD:461067	6/51 (12%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		3/12 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
gsb-n	NP_523862.1	HTH_CRP	20..141	CDD:481199	6/24 (25%)
		Homeodomain	183..239	CDD:459649	33/55 (60%)