Protein Alignment PITX3 and otp

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_001286654.1
• Gene: otp / 37364
• FlyBaseID: FBgn0015524
• Length: 416
• Species: Drosophila melanogaster
• Alignment Length: 276
• Identity: 84/276 - (30%)
• Similarity: 117/276 - (42%)
• Gaps: 57/276 - (20%)

Human    59 KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERS 123
            |.||:|.||.||..||.|||..|.:..|||:..|||||:...|||:||:|||:||||||:||:::
  Fly   113 KNKQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQVWFQNRRAKWKKRKKT 177

Human   124 QQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFN------------- 175
            ...      |..| |.|:|         |:|       .||..|.....|..
  Fly   178 TNV------FRTP-GALLP---------SHG-------LPPFGANITNIAMGDGLCGTGMFGGDR 219

Human   176 -SVNVGPLAS---QPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSS-GAV 235
             ||.|.|:.:   |...|.|.|.:.:...::....|:..|.|:.|..|....|.:.....| |.|
  Fly   220 WSVGVNPMTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGV 284

Human   236 SC-PYASAAAA------AAAAASSPYVYRDPCNSSLASL--------RLKAKQHASFSYPAVHGP 285
            || |..|.:|.      :.::.:.|.:...| |||...|        :.:.:|.........|..
  Fly   285 SCGPSGSPSATTPPNMNSCSSVTPPPLSAQP-NSSQNELNGEPMPLHQQQQQQTHQHQQQQTHQH 348

Human   286 PPAANLSPCQYAVERP 301
            .|.|..:|.|...:.|
  Fly   349 HPMAPPTPTQQQQQLP 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		7/11 (64%)
		Homeodomain	63..119	CDD:459649	33/55 (60%)
		OAR	258..275	CDD:461067	6/24 (25%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		4/20 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
otp	NP_001286654.1	Homeodomain	117..168	CDD:459649	28/50 (56%)