Protein Alignment PITX3 and lms

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_611491.2
• Gene: lms / 37322
• FlyBaseID: FBgn0034520
• Length: 378
• Species: Drosophila melanogaster
• Alignment Length: 303
• Identity: 80/303 - (26%)
• Similarity: 118/303 - (38%)
• Gaps: 73/303 - (24%)

Human     6 LSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGS--LKKKQRRQRTH 68
            |..:.|.|||.|              .|. .::.|..|:...|   :.:||:  ...:::|.||.
  Fly    46 LGASRASSPATS--------------SCL-DDNMDDGKSDIDL---ASDDGNGLGDDRKKRPRTA 92

Human    69 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSF 133
            |::.|::.||..|:|.:|..::.|..:|....|||.::::||:|||.|| ||:.:...|.....:
  Fly    93 FSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKW-KRKYTSDVETLASHY 156

Human   134 AAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASM 198
            .|.||              .|     .||.|:......:.|:....||...|.:....|..||.|
  Fly   157 YAQLG--------------IG-----GLARPMVVGDRLWLFSQTPTGPTPIQSIMLNGSGSAAPM 202

Human   199 VPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSS------------------GAVSCPYASAAAA 245
            . ||..|.|:...|.|..  ||.||...|:.:.|                  |....|.....||
  Fly   203 A-SATTATGSPMRPYATS--GGMPPLPGPSVMESARNAILARGQPLNFALPFGVAKPPAGGVPAA 264

Human   246 AAAAASSPYV--YRD-----PCNSS-----LASLRLKAKQHAS 276
            :......||.  |.|     |.|.|     .|:|..:|:..||
  Fly   265 SYIPRCKPYATSYVDYAASLPTNESYLQMKYATLPPEAESGAS 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		16/66 (24%)
		Homeodomain	63..119	CDD:459649	22/55 (40%)
		OAR	258..275	CDD:461067	7/26 (27%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		4/17 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
lms	NP_611491.2	Cnd2	33..>106	CDD:450400	19/77 (25%)
		Homeodomain	87..143	CDD:459649	22/56 (39%)