Protein Alignment PITX3 and cad

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Alignment Length: 277
• Identity: 67/277 - (24%)
• Similarity: 99/277 - (35%)
• Gaps: 91/277 - (32%)

Human     6 LSEAEARSPALSLSDAGTPHPQLPEH-----------------------GCKGQEHSDSEKASAS 47
            :|.:|..||....| |.:||..|..|                       .......|::.:.|.|
  Fly   185 VSGSEISSPGAPTS-ASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPS 248

Human    48 LP-------------------GGSPE--------DGSLKKKQR-RQRTHFTSQQLQELEATFQRN 84
            .|                   ..||.        |.|.|.:.: :.|..:|..|..|||..:..:
  Fly   249 KPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTS 313

Human    85 RYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLG---------GL 140
            ||..:..:.|:|...:|:|.:|::||:|||||.||:.:       |||....:|         .|
  Fly   314 RYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNK-------KGSDPNVMGVGVQHADYSQL 371

Human   141 VPPYEEVYPGYSYG-------------NWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPS 192
            :....::.||....             |.|...|.|.|||.:...|..:.:...|..|.
  Fly   372 LDAKAKLEPGLHLSHSLAHSMNPMAAMNIPAMRLHPHLAAHSHSLAAVAAHSHQLQQQH------ 430

Human   193 SIAASMVPSAAAAPGTV 209
              :|.|  |||||.||:
  Fly   431 --SAQM--SAAAAVGTL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		20/115 (17%)
		Homeodomain	63..119	CDD:459649	20/56 (36%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	20/54 (37%)