Protein Alignment PITX3 and CG11085

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_572815.3
• Gene: CG11085 / 32213
• FlyBaseID: FBgn0030408
• Length: 295
• Species: Drosophila melanogaster
• Alignment Length: 292
• Identity: 70/292 - (23%)
• Similarity: 100/292 - (34%)
• Gaps: 108/292 - (36%)

Human     4 GLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLK--------- 59
            ||.:.|.|...|..|..|..       .|..|..  |:...|....||....|..:
  Fly   102 GLSAAAAAAGVAAGLLAAAA-------SGANGDR--DANGGSGPGSGGGTSGGYAEHKLQLSKSG 157

Human    60 KKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQ 124
            :|.||:||.||..||..||..|:..:|..::.|.::|...||:|.:|:.|::|||.||:::
  Fly   158 RKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQ---- 218

Human   125 QAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFS 189
                                                              |.:.:..|..|
  Fly   219 --------------------------------------------------NQLRLEQLRHQ---- 229

Human   190 PPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPY 254
                  |:|........|     |...|||..|.||:.:           .|||||||||||
  Fly   230 ------ATMEKDFVVQDG-----GGAGGLGCCPSGLSSS-----------FSAAAAAAAAAS--- 269

Human   255 VYRDPCNSSLASLRLKAKQHASFSYPAVHGPP 286
               :|||...::......::..:    |||.|
  Fly   270 ---NPCNFLTSAAAAAIFRNVGY----VHGCP 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		20/75 (27%)
		Homeodomain	63..119	CDD:459649	24/55 (44%)
		OAR	258..275	CDD:461067	3/16 (19%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		0/12 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
CG11085	NP_572815.3	Homeodomain	161..217	CDD:459649	24/55 (44%)