Protein Alignment PITX3 and Vsx2

DIOPT Version :10

• Sequence 1: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 102/406 - (25%)
• Similarity: 148/406 - (36%)
• Gaps: 163/406 - (40%)

Human    25 HPQLPEH---GCKG--QEHSDSEKASASLPGG-SPEDGSL---------------KKKQRRQRTH 68
            ||..|.|   ..:|  |..|.:..|...|||. :|:|..:               |||:|..||.
  Fly   172 HPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNSKKKKKKRRHSRTI 236

Human    69 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER-----SQQAEL 128
            |||.||::||..|:...|||:..||.:::.|.|.|.|::|||:||||||||.|:     :..||.
  Fly   237 FTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEY 301

Human   129 CKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPL---------------------------- 165
              |.:.|.:...:|..:.:.......:    |:||.|
  Fly   302 --GLYGAMVRHSLPLPDTILKSAKDND----AVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDH 360

Human   166 --------------------AAKTFPFAFNSVNVGPLA---SQPVFSPPSSIA--ASMVPSAAAA 205
                                |..:...:.|.|:..|.:   |....:||:|.:  |....|||..
  Fly   361 EDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATT 425

Human   206 P----------------GTVPGPGALQGL---------------------GGGPPGLAP---AAV 230
            |                |: |.|...|.|                     |..||...|   ||.
  Fly   426 PTGASTTNSSSSPHIELGS-PSPQQQQHLQLQQQQQQQASLYLGAGAVVTGCAPPSYHPLLDAAN 489

Human   231 SSGA------------VSCPYASAAAAA------------AAAASSPYVY----------RDP-- 259
            ::||            ::...|:|||||            .|.|::|.::          .||
  Fly   490 AAGAGAAASSKDFHMIMNTAVAAAAAAAQQQHQQQQQQQQQATATAPGLHAHNLAAALMEHDPDA 554

Human   260 -CNSSLASLRLKAKQH 274
             .|:|:|.||.||::|
  Fly   555 FRNNSIACLRAKAQEH 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		20/66 (30%)
		Homeodomain	63..119	CDD:459649	29/55 (53%)
		OAR	258..275	CDD:461067	10/20 (50%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		7/13 (54%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		2/3 (67%)
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	29/56 (52%)
		OAR	556..572	CDD:461067	8/15 (53%)