Protein Alignment PITX2 and hbn

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 306
• Identity: 94/306 - (30%)
• Similarity: 139/306 - (45%)
• Gaps: 55/306 - (17%)

Human     6 GPLHLEHRAAGTKLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAEK 70
            |..||.|:.     ....|...||.|        ...|.:.|.....|.:..|.:| ...:....
  Fly    81 GSNHLSHQQ-----QQQHSQQQHHSQ--------QQQQQQQLQVQAKREDSPTNTD-GGLDVDND 131

Human    71 DKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEAR 135
            |:.....|......|..:.::.||.||.||:.||.:||..|::.:|||:.|||::|:..:|:|||
  Fly   132 DELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEAR 196

Human   136 VRVWFKNRRAKWRKRER--NQQAE---LCKNGFGPQF--------------NGLMQ-----PYDD 176
            |:|||:||||||||||:  ||...   |.:.|. |:|              .|.||     |:..
  Fly   197 VQVWFQNRRAKWRKREKFMNQDKAGYLLPEQGL-PEFPLGIPLPPHGLPGHPGSMQSEFWPPHFA 260

Human   177 MYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSM-FSPPNSISSMSMSSSMVPSAVTG 240
            ::..::....||.||....|..   |.:...|.:.|.||.| .|..|.|.... :::...:|..|
  Fly   261 LHQHFNPAAAAAAGLLPQHLMA---PHYKLPNFHTLLSQYMGLSNLNGIFGAG-AAAAAAAASAG 321

Human   241 VPGS-SLNS-LNNLNNLSSPSLNSA-------VPTPACPYAPPTPP 277
            .|.: ||:: |:.::.:|.|..||:       ||.|..|:|  |||
  Fly   322 YPQNLSLHAGLSAMSQVSPPCSNSSPRESPKLVPHPTPPHA--TPP 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	32/55 (58%)
		OAR	282..299	CDD:461067
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	32/55 (58%)