Protein Alignment PITX2 and gsb-n

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_523862.1
• Gene: gsb-n / 38004
• FlyBaseID: FBgn0001147
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 321
• Identity: 84/321 - (26%)
• Similarity: 128/321 - (39%)
• Gaps: 93/321 - (28%)

Human    60 SDTSSPEAAEKDKSQQ----GKNEDVGAEDPSK----KKRQRRQRTHFTSQQLQELEATFQRNRY 116
            ||..| |...||.:..    |::.|:...:...    |::|||.||.||::||:.||..|.|.:|
  Fly   143 SDRGS-EDGRKDYTINGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQY 206

Human   117 PDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGY 181
            ||:.||||:|..|.|||||::|||.||||:.||.....     .:|..|..:|
  Fly   207 PDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGS-----NSGLSPMNSG------------ 254

Human   182 SYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSM--FSP---------------------PNS 223
            |.|.....||:.|:.         .:...||...||  :||                     |:|
  Fly   255 SSNVGVGVGLSGATA---------PLGYGPLGVGSMAGYSPAPGTTATGAGMNDGVHHAAHAPSS 310

Human   224 ISSMSMSSS------------MVPSAVT-GVPGS-----------------SLNSLNNLNNLSSP 258
            ..|.:.:::            :|.||.. |.||.                 |..::::.:.|::.
  Fly   311 HHSAATAAAAAHHHTQMGGYDLVQSAAQHGFPGGFAQPGHFGSQNYYHQDYSKLTIDDFSKLTAD 375

Human   259 SLNSAVPT--PACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQ---NPASNLS 314
            |::...|:  .:..|:....|..:......:.|:......||....||:..   ||||..|
  Fly   376 SVSKISPSLHLSDNYSKLEAPSNWSQAAYHAAANYNAHVAQHQLNDYAAAAAHGNPASAYS 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	33/55 (60%)
		OAR	282..299	CDD:461067	2/16 (13%)
gsb-n	NP_523862.1	HTH_CRP	20..141	CDD:481199
		Homeodomain	183..239	CDD:459649	33/55 (60%)