Protein Alignment PITX2 and Dll

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Alignment Length: 319
• Identity: 86/319 - (26%)
• Similarity: 132/319 - (41%)
• Gaps: 49/319 - (15%)

Human    11 EHRAAGTKLSAVSSSSCHH-PQ-------PLAMASVLAPGQPRSLDS-SKHRLEVHTISDTSSPE 66
            :|.|||  ...:.|:..|. ||       |...:::..|..|...:| |.:.|..:.....|.|
  Fly    39 QHAAAG--YGGIRSTYQHFGPQGGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPP- 100

Human    67 AAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNL 131
              :.|.|...|.||.|.....|.|:.|:.||.::|.|||:|...|||.:|..:..|.|:|....|
  Fly   101 --KDDFSISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGL 163

Human   132 TEARVRVWFKNRRAKWRKRERNQQAELCKNGF-----GPQFNGLMQPYDDMYPGYSYNN---WAA 188
            |:.:|::||:|||:|::|..:..|.....:|.     ||. .|...| :.|:.|...|.   |||
  Fly   164 TQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPN-PGQHSP-NQMHSGELANGRFLWAA 226

Human   189 KGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNN-- 251
            .. |:.:|:.......|:...:...|.|.:.||.  .|.:.||:.|.......|.:.|:....
  Fly   227 LE-TNGTLALVHSTGGNNGGGSNSGSPSHYLPPG--HSPTPSSTPVSELSPEFPPTGLSPPTQAP 288

Human   252 -------LNNLSSPSLNSAVPTPACPYAPPT-------------PPYVYRDTCNSSLAS 290
                   :::...|.:....|.||....|.|             |.|.|:...|.||.:
  Fly   289 WDQKPHWIDHKPPPQMTPQPPHPAATLHPQTHHHNPPPQMGGYVPQYWYQPETNPSLVT 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	24/55 (44%)
		OAR	282..299	CDD:461067	3/9 (33%)
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)