Protein Alignment PITX2 and otp

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_001286654.1
• Gene: otp / 37364
• FlyBaseID: FBgn0015524
• Length: 416
• Species: Drosophila melanogaster
• Alignment Length: 327
• Identity: 86/327 - (26%)
• Similarity: 124/327 - (37%)
• Gaps: 124/327 - (37%)

Human    74 QQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRV 138
            ||.::.|        |.:|:|.||.||..||.|||..|.:..|||:..|||||:...|||:||:|
  Fly   106 QQDQHLD--------KNKQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQV 162

Human   139 WFKNRRAKWRKRERNQQA---------------------------ELCKNGF--GPQFNGLMQPY 174
            ||:||||||:||::....                           .||..|.  |.:::..:.|
  Fly   163 WFQNRRAKWKKRKKTTNVFRTPGALLPSHGLPPFGANITNIAMGDGLCGTGMFGGDRWSVGVNP- 226

Human   175 DDMYPGYSYNNWAA-------KGLTS-----ASLSTKSFPFF---------------NSMNVNPL 212
              |..|:...|.::       .||.|     ::|...|:..:               ..::..|.
  Fly   227 --MTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGVSCGPS 289

Human   213 SSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPA--------- 268
            .|.|..:|||    |:..||:.|..::..|.||.|.||            ..|.|.
  Fly   290 GSPSATTPPN----MNSCSSVTPPPLSAQPNSSQNELN------------GEPMPLHQQQQQQTH 338

Human   269 ----------CPYAPPTPPYVYR----------DTCNSSLASLRLKAKQHSSFGYASVQNPASNL 313
                      .|.|||||....:          |..|.:|.|:            |:::..||.|
  Fly   339 QHQQQQTHQHHPMAPPTPTQQQQQLPQSMQSPSDGANDTLHSI------------AALRRRASEL 391

Human   314 SA 315
            :|
  Fly   392 NA 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	33/55 (60%)
		OAR	282..299	CDD:461067	4/16 (25%)
otp	NP_001286654.1	Homeodomain	117..168	CDD:459649	28/50 (56%)