Protein Alignment PITX2 and lms

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_611491.2
• Gene: lms / 37322
• FlyBaseID: FBgn0034520
• Length: 378
• Species: Drosophila melanogaster
• Alignment Length: 335
• Identity: 83/335 - (24%)
• Similarity: 138/335 - (41%)
• Gaps: 70/335 - (20%)

Human    29 HPQPLAMASVLAPGQPRSLDSSKHRLEVHT--------ISDTSSPEAAE--KDKSQQGKNE-DVG 82
            :|...::..:||..:.||..|.:..::..:        .|..|||..:.  .|....||:: |:.
  Fly    10 YPHSFSIEQILAKPEMRSSTSFEDSVQDESGRGGNCLGASRASSPATSSCLDDNMDDGKSDIDLA 74

Human    83 AEDPS--KKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRA 145
            ::|.:  ...|::|.||.|::.|::.||..|:|.:|..::.|..:|....|||.::::||:|||.
  Fly    75 SDDGNGLGDDRKKRPRTAFSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRT 139

Human   146 KWRKRERNQQAELCKNGFGPQ--FNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMN 208
            || ||:.....|...:.:..|  ..||.:|   |..|...  |                .|:...
  Fly   140 KW-KRKYTSDVETLASHYYAQLGIGGLARP---MVVGDRL--W----------------LFSQTP 182

Human   209 VNPLSSQSMF------SPPNSISSMSMSSSMVPSAVTG----VPGSS-LNSLNNLNNLSSPSLNS 262
            ..|...||:.      :.|.:.::.:..|.|.|.|.:|    :||.| :.|..|........||.
  Fly   183 TGPTPIQSIMLNGSGSAAPMASATTATGSPMRPYATSGGMPPLPGPSVMESARNAILARGQPLNF 247

Human   263 AVP----------TPACPYAPPTPPYV--YRDTCNS----------SLASLRLKAKQHSSFGYAS 305
            |:|          .||..|.|...||.  |.|...|          ..|:|..:|:..:|.|.|.
  Fly   248 ALPFGVAKPPAGGVPAASYIPRCKPYATSYVDYAASLPTNESYLQMKYATLPPEAESGASNGLAE 312

Human   306 VQNPASNLSA 315
            ::....:.:|
  Fly   313 LERVFGDANA 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	22/55 (40%)
		OAR	282..299	CDD:461067	5/26 (19%)
lms	NP_611491.2	Cnd2	33..>106	CDD:450400	17/72 (24%)
		Homeodomain	87..143	CDD:459649	22/56 (39%)