DRSC/TRiP Functional Genomics Resources

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Protein Alignment PITX2 and al

DIOPT Version :10

Sequence 1:NP_000316.2 Gene:PITX2 / 5308 HGNCID:9005 Length:324 Species:Homo sapiens
Sequence 2:NP_722629.1 Gene:al / 33208 FlyBaseID:FBgn0000061 Length:408 Species:Drosophila melanogaster


Alignment Length:409 Identity:107/409 - (26%)
Similarity:156/409 - (38%) Gaps:164/409 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    10 LEHRAAGTKLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQ 74
            |..||.|:  ||.|:.:.     |.::..::.|.|.....:.        ..|:||.:       
  Fly    26 LVDRAPGS--SAASAGAA-----LTVSMSVSGGAPSGASGAS--------GGTNSPVS------- 68

Human    75 QGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVW 139
             ..|.|..|::.:.|::|||.||.|||.||:|||..|.|..|||:.||||:|:...|||||::||
  Fly    69 -DGNSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVW 132

Human   140 FKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLT------------ 192
            |:||||||||:|:          .|||    ..||:...||.:.......|..            
  Fly   133 FQNRRAKWRKQEK----------VGPQ----SHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQ 183

Human   193 ---------SASLSTKSFP-----------FFNSM-----NVNPLSSQSMFSPPNSISSMSMSSS 232
                     :|:|:...:|           :||..     ::.|.....|:||.:|..|:..:.:
  Fly   184 LRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSSFQSLLANMT 248

Human   233 MV---------PSAVTGVPGSSLNSLNNLNNLSSPSLNSAV---------PT--PACPYAPP--- 274
            .|         |:.:.|.|  .|:|.|::  |:||..:.|.         ||  |..|.|||   
  Fly   249 AVPRGTPLGKPPALLVGSP--DLHSPNHM--LASPPTSPASGHASQHQQHPTAHPPPPQAPPQMP 309

Human   275 ------------------------------------------------------------TPPYV 279
                                                                        |||  
  Fly   310 VGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSPQRQLPPPSHQAPPPPPRAATPP-- 372

Human   280 YRDTCNSSLASLRLKAKQH 298
             .|...||:|:|||||::|
  Fly   373 -EDRRTSSIAALRLKAREH 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PITX2NP_000316.2 Homeodomain 93..149 CDD:459649 36/55 (65%)
OAR 282..299 CDD:461067 10/17 (59%)
alNP_722629.1 Homeodomain 86..142 CDD:459649 36/55 (65%)
OAR 374..391 CDD:461067 10/17 (59%)

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